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World J Radiol. Apr 28, 2025; 17(4): 105722
Published online Apr 28, 2025. doi: 10.4329/wjr.v17.i4.105722
Clinical translation of ultra-high dose rate flash radiotherapy: Opportunities, challenges, and prospects
Xiang-Xiang Yang, Hui Luo, Jia-Jun Zhang, Heng Ge, Liang Ge
Xiang-Xiang Yang, Jia-Jun Zhang, Liang Ge, Department of Medical Imaging, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, Henan Province, China
Hui Luo, Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou 450003, Henan Province, China
Heng Ge, Department of Oncology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, Henan Province, China
Co-corresponding authors: Heng Ge and Liang Ge.
Author contributions: Yang XX and Ge L conceptualized and designed the study; Yang XX, Luo H, Zhang JJ, Ge H, Ge L contributed meaningfully to the preparation of the manuscript, conducted the literature review, did the analysis, drafted the original manuscript, and made critical revisions; Ge L and Ge H supervised the review, advised the review design, and critically revised the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liang Ge, PhD, Assistant Professor, Department of Medical Imaging, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou 450001, Henan Province, China. zl13703920959@sina.com
Received: February 5, 2025
Revised: March 9, 2025
Accepted: March 25, 2025
Published online: April 28, 2025
Processing time: 76 Days and 18.8 Hours
Core Tip

Core Tip: Ultra-high dose rate flash radiotherapy (FLASH-RT) has garnered significant attention due to its unique high-efficiency and low-toxicity biological effects. With an increasing number of research teams entering this field, the number of related publications has grown exponentially. While the high-efficiency and low-toxicity characteristics of FLASH-RT have been extensively validated, it is equally crucial to objectively analyze relevant negative findings. This article systematically synthesizes published research data to elucidate the advance of FLASH-RT. These findings provide valuable references for designing future FLASH-RT preclinical experimental protocols and facilitating clinical translation.