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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Feb 26, 2026; 18(2): 114265
Published online Feb 26, 2026. doi: 10.4330/wjc.v18.i2.114265
Published online Feb 26, 2026. doi: 10.4330/wjc.v18.i2.114265
Oral anticoagulant therapy and outcomes in new-onset atrial fibrillation during acute myocardial infarction: A systematic review and meta-analysis
Kristina G Pereverzeva, Ayoub Glenza, Sergey S Yakushin, Department of Hospital Therapy, Federal State Budgetary Educational Institution of Higher Education, Ryazan State Medical University, Ryazan 390026, Ryazanskaya Oblast, Russia
Author contributions: Pereverzeva KG contributed to the study conceptualization, methodology, and supervision of the project; Pereverzeva KG and Glenza A contributed to data curation and drafting of the manuscript; Pereverzeva KG, Glenza A, and Yakushin SS contributed to editing of the subsequent versions; Glenza A performed the literature review; Yakushin SS provided critical resources, contributed to the reviewing of the various manuscript versions, and performed project administration. All authors read and approved the final version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kristina G Pereverzeva, MD, PhD, Professor, Department of Hospital Therapy, Federal State Budgetary Educational Institution of Higher Education, Ryazan State Medical University, 96 Stroykova Street, Ryazan 390026, Ryazanskaya Oblast, Russia.
Received: September 15, 2025
Revised: October 2, 2025
Accepted: December 10, 2025
Published online: February 26, 2026
Processing time: 147 Days and 11.3 Hours
Revised: October 2, 2025
Accepted: December 10, 2025
Published online: February 26, 2026
Processing time: 147 Days and 11.3 Hours
Core Tip
Core Tip: New-onset atrial fibrillation during acute myocardial infarction is a frequent and high-risk complication, yet evidence for optimal long-term management is limited due to exclusion from randomized trials. This meta-analysis of 7158 patients demonstrated that oral anticoagulant therapy reduced all-cause mortality by 25% without increasing major bleeding risk. The findings support guideline recommendations to consider anticoagulation in this population, particularly in patients with higher thromboembolic risk. Importantly, the results highlighted the urgent need for randomized trials focusing on direct oral anticoagulants and transient atrial fibrillation in the context of acute myocardial infarction.