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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Oct 26, 2025; 17(10): 111941
Published online Oct 26, 2025. doi: 10.4330/wjc.v17.i10.111941
Published online Oct 26, 2025. doi: 10.4330/wjc.v17.i10.111941
Dual versus single antiplatelet therapy after lower extremity revascularization in peripheral artery disease: A systematic review and meta-analysis
Mohammad Maroof Shahid, Absar Mukhtar, Hooria Ejaz, Muhammad Soban Jaffar, Mavia Habib, Mirza Muhammad Hadeed Khawar, Department of Cardiology, Services Institute of Medical Sciences, Lahore 54000, Punjab, Pakistan
Debvarsha Mandal, Department of Cardiology, Avalon University School of Medicine, Willemstad 4797, Netherlands
Ashesh Das, Department of Cardiology, KPC Medical College and Hospital, Kolkata 700001, West Bengal, India
Pershan Kumar, Department of Cardiology, Jinnah Postgraduate Medical Centre, Karachi 10017, Sindh, Pakistan
Nikil Kumar, Department of Cardiology, Jinnah Medical and Dental College, Karachi 74000, Sindh, Pakistan
Ayesha Afzal, Department of Cardiology, Faisalabad Medical University, Faisalabad 38000, Punjab, Pakistan
Ikra Rana, Department of Medicine, International School of Medicine, International University of Kyrgyzstan, Bishkek 720074, Kyrgyzstan
Co-first authors: Mohammad Maroof Shahid and Debvarsha Mandal.
Author contributions: Shahid MM, Mandal D, and Das A led conceptualization, methodology and formal analysis, wrote and reviewed the manuscript; Kumar P, Kumar N, and Mukhtar A led software, validation, investigation, wrote and reviewed the manuscript; Ejaz H, Jaffar MS, Habib M, Afzal A, and Khawar MMH wrote and reviewed the manuscript; Rana I supervised the project, led data curation, wrote and reviewed the manuscript; all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ikra Rana, MD, Department of Medicine, International School of Medicine, International University of Kyrgyzstan, 6 Street, Bishkek 720074, Kyrgyzstan.
Received: July 14, 2025
Revised: July 29, 2025
Accepted: August 25, 2025
Published online: October 26, 2025
Processing time: 102 Days and 21.4 Hours
Revised: July 29, 2025
Accepted: August 25, 2025
Published online: October 26, 2025
Processing time: 102 Days and 21.4 Hours
Core Tip
Core Tip: This meta-analysis synthesizes evidence from randomized controlled trials and cohort studies to compare dual antiplatelet therapy (DAPT) and single antiplatelet therapy (SAPT) following lower extremity revascularization in patients with peripheral artery disease (PAD). The findings demonstrate that DAPT is associated with reduced cardiac mortality, myocardial infarction, and major reintervention risk compared to SAPT, without a significant increase in bleeding complications. These results support the short-term use of DAPT in PAD management post-revascularization and inform current clinical guidelines.