Clinical significance of systemic inflammation response index and platelet–lymphocyte ratio in patients with stage I-III gastric cancer

Table 1 Characteristics of training and validation cohorts

Clinicopathologic factors	Training set				P value	Validation set				P value
	Score 0	Score 1	Score 2	Statistic		Score 0	Score 1	Score 2	Statistic
Sex				χ² = 6.85	0.033				χ² = 5.66	0.059
Male	125	245	199			50	113	80
Female	57	65	60			26	29	22
Age (years)				χ² = 1.46	0.481				χ² = 3.80	0.15
≤ 65	112	190	147			51	76	58
> 65	70	120	112			25	66	44
Surgical approach				-	0.176				-	0.03
Open	154	277	234			63	129	88
Laparoscopic	27	32	22			8	11	14
Robotic	1	3	1			5	2	0
Tumor location				χ² = 8.54	0.074				χ² = 0.74	0.946
Cardia and fundus of stomach	98	160	123			36	67	48
Gastric body	27	64	68			13	24	21
Pylorus	57	86	68			27	51	33
Tumor site				χ² = 13.26	0.103				-	0.072
Lesser curvature side	148	246	193			67	114	77
Greater curvature side	20	31	23			5	19	7
Anterior wall	7	15	15			1	3	6
Posterior wall	3	14	16			1	4	8
Total stomach	4	4	12			2	2	4
Pathological type				χ² = 0.10	0.952				χ² = 0.95	0.622
Adenocarcinoma	173	293	246			71	136	95
Others	9	17	13			5	6	7
Differentiation degree				-	0.1751				-	0.196
Poorly differentiated	130	235	177			60	92	68
Moderately differentiated	50	72	81			16	48	33
Highly differentiated	2	3	1			0	2	1
Tumor size				χ² = 68.59	< 0.001				χ² = 2.26	0.323
≤ 5	143	231	119			52	102	64
> 5	39	79	140			24	40	38
T stage				χ² = 28.96	< 0.001				χ² = 13.33	0.038
T1	37	58	21			19	31	13
T2	22	31	15			14	19	8
T3	15	40	27			8	13	8
T4	108	181	196			35	79	73
N stage				χ² = 10.62	0.101				χ² = 13.84	0.031
N0	73	129	83			43	64	38
N1	32	51	42			7	33	17
N2	38	63	52			10	19	15
N3	39	67	82			16	26	32
Neutrophil-to-lymphocyte ratio				χ² = 183.54	< 0.001				χ² = 80.27	< 0.001
≤ 2.98	181	276	132			76	126	51
> 2.98	1	34	127			0	16	51
Systemic immune-inflammation index				χ² = 344.47	< 0.001				χ² = 153.51	< 0.001
≤ 560.54	182	267	68			76	125	26
> 560.54	0	43	191			0	17	76
Carcinoembryonic antigen				χ² = 2.39	0.303				χ² = 2.06	0.358
≤ 4.02	130	211	167			52	106	68
> 4.02	52	99	92			24	36	34

¹Fisher's exact test, simulated P value.

Table 2 Univariate and multivariate analyses for predicting the survival outcomes of the training cohort

Clinicopathologic factors	Univariate analysis			Multivariate analysis
	Exp(B)	95.0%CI of Exp(B)	P value	Exp(B)	95.0%CI of Exp(B)	P value
Sex	0.961	0.749-1.233	0.752
Age	1.431	1.157-1.770	0.001	1.364	1.098-1.693	0.005
Surgical approach			0.396
Open	1.000
Laparoscopic	0.788	0.545-1.140	0.206
Robotic	0.730	0.234-2.276	0.587
Tumor location			0.023			0.058
Cardia and fundus of stomach	1.000			1.000
Gastric body	1.257	0.965-1.638	0.090	1.386	1.056-1.818	0.019
Pylorus	0.825	0.639-1.066	0.141	1.176	0.899-1.537	0.237
Tumor site			0.419
Lesser curvature side	1.000
Greater curvature side	1.242	0.891-1.732	0.201
Anterior wall	0.638	0.340-1.200	0.164
Posterior wall	1.004	0.587-1.719	0.987
Total stomach	1.107	0.570-2.151	0.764
Pathological type	0.834	0.505-1.378	0.479
Differentiation degree			0.202
Poorly differentiated	1.000
Moderately differentiated	0.800	0.627-1.022	0.074
Highly differentiated	0.000	0.000-2.60E+107	0.933
Tumor size	2.345	1.896-2.901	0.000	1.283	1.014-1.623	0.038
T stage			0.000			0.000
T1	1.000			1.000
T2	2.176	1.057-4.480	0.035	1.699	0.820-3.523	0.154
T3	4.776	2.514-9.075	0.000	2.468	1.261-4.830	0.008
T4	7.137	4.092-12.449	0.000	3.480	1.924-6.296	0.000
N stage			0.000			0.000
N0	1.000			1.000
N1	2.116	1.474-3.037	0.000	1.508	1.040-2.186	0.030
N2	3.214	2.321-4.449	0.000	2.064	1.470-2.897	0.000
N3	4.777	3.564-6.403	0.000	2.491	1.805-3.440	0.000
Systemic inflammation response index-platelet-to-lymphocyte ratio			0.000			0.013
0	1.000			1.000
1	1.421	1.040-1.943	0.028	1.444	1.051-1.982	0.023
2	2.297	1.691-3.120	0.000	1.759	1.204-2.571	0.004
Neutrophil-to-lymphocyte ratio	1.463	1.153-1.857	0.002	0.912	0.677-1.229	0.545
Systemic immune-inflammation index	1.669	1.343-2.074	0.000	1.037	0.750-1.434	0.825
Carcinoembryonic antigen	2.512	2.030-3.109	0.000	2.049	1.643-2.556	0.000