Zhou EZ, Zhang LX, Han WX, Xu AM, Wei ZJ. Clinical significance of systemic inflammation response index and platelet–lymphocyte ratio in patients with stage I-III gastric cancer. World J Gastrointest Surg 2025; 17(10): 110801 [DOI: 10.4240/wjgs.v17.i10.110801]
Corresponding Author of This Article
Zhi-Jian Wei, Chief Physician, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230032, Anhui Province, China. zhou11012025@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 27, 2025 (publication date) through Oct 24, 2025
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Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Zhou EZ, Zhang LX, Han WX, Xu AM, Wei ZJ. Clinical significance of systemic inflammation response index and platelet–lymphocyte ratio in patients with stage I-III gastric cancer. World J Gastrointest Surg 2025; 17(10): 110801 [DOI: 10.4240/wjgs.v17.i10.110801]
En-Ze Zhou, Wen-Xiu Han, A-Man Xu, Zhi-Jian Wei, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
Li-Xiang Zhang, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
Co-first authors: En-Ze Zhou and Li-Xiang Zhang.
Co-corresponding authors: A-Man Xu and Zhi-Jian Wei.
Author contributions: Zhou EZ drafted the initial version of the paper; Zhang LX was in charge of collecting and analyzing all data as well as drawing the charts; Zhou EZ and Zhang LX have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper; Han WX reviewed and revised the paper; Xu AM and Wei ZJ conceptualized and designed this study, played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors; all authors read and approved the final paper.
Supported by Key Projects of Anhui Provincial Department of Education, No. 2023AH053330.
Institutional review board statement: Our study was approved by The Ethics Committee of The First Affiliated Hospital of Anhui Medical University, No. PJ 2025-01-61.
Informed consent statement: This study protocol is exempt from obtaining informed consent and has been approved by The Ethics Committee of The First Affiliated Hospital of Anhui Medical University.
Conflict-of-interest statement: All of the authors read and approved the final version of the manuscript to be published.
Data sharing statement: For this study, the data supporting the research findings can be obtained from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Jian Wei, Chief Physician, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230032, Anhui Province, China. zhou11012025@163.com
Received: June 16, 2025 Revised: July 3, 2025 Accepted: August 13, 2025 Published online: October 27, 2025 Processing time: 130 Days and 12.6 Hours
Abstract
BACKGROUND
Gastric cancer (GC) has a relatively high incidence and mortality rate. Surgery is the primary treatment; however, the survival rate of patients remains low. Therefore, there is an urgent need to identify simple and feasible prognostic indicators for GC. As an inflammation-related biomarker, the systemic inflammation response index (SIRI), platelet-to-lymphocyte ratio (PLR), and SIRI-PLR can be obtained from routine blood tests. Compared with existing prognostic indicators, which are expensive and rely on complex analyses, SIRI-PLR offers extremely high convenience and cost-effectiveness.
AIM
To explore the impact of SIRI-PLR on the prognosis of patients with stage I–III GC after surgery and construct a nomogram.
METHODS
We retrospectively analyzed the clinical and pathological data of patients with GC who underwent radical surgery at The First Affiliated Hospital of Anhui Medical University between January 2014 and December 2017. A total of 1071 patients with clear clinical prognoses were selected. Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors associated with overall survival in patients with GC, and a nomogram prediction model was constructed.
RESULTS
Multivariate Cox regression analysis revealed that age, tumor size, T stage, N stage, SIRI-PLR, and carcinoembryonic antigen were independent prognostic factors. The areas under the curve of the nomogram for training and validation sets were 0.821 and 0.848, respectively. Calibration plots and decision curve analyses demonstrated that the nomogram exhibited good predictive performance and clinical utility in training and validation cohorts.
CONCLUSION
Preoperative SIRI-PLR was significantly associated with the prognosis of patients with stage I–III GC following radical gastrectomy. Our nomogram could serve as an essential tool for clinicians to predict the postoperative prognosis of patients with stage I–III GC.
Core Tip: In this study, 1071 patients with stage I-III gastric cancer who underwent radical gastrectomy at The First Affiliated Hospital of Anhui Medical University were followed up, and relevant clinicopathological factors were collected. A new scoring system called systemic inflammation response index (SIRI)-platelet-to-lymphocyte ratio (PLR) was calculated. Through univariate and multivariate Cox regression analyses, six indicators significantly associated with survival were identified: Age, tumor size, T stage, N stage, SIRI-PLR, and carcinoembryonic antigen. A nomogram model was then constructed and validated.
