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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2025; 17(10): 110801
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.110801
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.110801
Clinical significance of systemic inflammation response index and platelet–lymphocyte ratio in patients with stage I-III gastric cancer
En-Ze Zhou, Wen-Xiu Han, A-Man Xu, Zhi-Jian Wei, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
Li-Xiang Zhang, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
Co-first authors: En-Ze Zhou and Li-Xiang Zhang.
Co-corresponding authors: A-Man Xu and Zhi-Jian Wei.
Author contributions: Zhou EZ drafted the initial version of the paper; Zhang LX was in charge of collecting and analyzing all data as well as drawing the charts; Zhou EZ and Zhang LX have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper; Han WX reviewed and revised the paper; Xu AM and Wei ZJ conceptualized and designed this study, played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors; all authors read and approved the final paper.
Supported by Key Projects of Anhui Provincial Department of Education, No. 2023AH053330.
Institutional review board statement: Our study was approved by The Ethics Committee of The First Affiliated Hospital of Anhui Medical University, No. PJ 2025-01-61.
Informed consent statement: This study protocol is exempt from obtaining informed consent and has been approved by The Ethics Committee of The First Affiliated Hospital of Anhui Medical University.
Conflict-of-interest statement: All of the authors read and approved the final version of the manuscript to be published.
Data sharing statement: For this study, the data supporting the research findings can be obtained from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Jian Wei, Chief Physician, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230032, Anhui Province, China. zhou11012025@163.com
Received: June 16, 2025
Revised: July 3, 2025
Accepted: August 13, 2025
Published online: October 27, 2025
Processing time: 130 Days and 15 Hours
Revised: July 3, 2025
Accepted: August 13, 2025
Published online: October 27, 2025
Processing time: 130 Days and 15 Hours
Core Tip
Core Tip: In this study, 1071 patients with stage I-III gastric cancer who underwent radical gastrectomy at The First Affiliated Hospital of Anhui Medical University were followed up, and relevant clinicopathological factors were collected. A new scoring system called systemic inflammation response index (SIRI)-platelet-to-lymphocyte ratio (PLR) was calculated. Through univariate and multivariate Cox regression analyses, six indicators significantly associated with survival were identified: Age, tumor size, T stage, N stage, SIRI-PLR, and carcinoembryonic antigen. A nomogram model was then constructed and validated.