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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2026; 18(1): 114697
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.114697
Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.114697
Mesenteric Castleman disease: Two case reports and review of literature
Se-Niu Jizhi, Department of Clinical Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Se-Niu Jizhi, Xing-Yu Chen, Shan-Shan Wu, Zhong-Lu Chen, A-Niu Liu, Shu-Mei Zheng, Department of Gastroenterology and Hepatology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China
Author contributions: Zheng SM designed the report; Jizhi SN and Chen XY collected the patient’s clinical data; Wu SS and Liu AN analyzed the radiological imaging; Chen ZL analyzed the histological and immunohistochemical images; Jizhi SN and Zheng SM wrote the paper; all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient’s relatives for the publication of this report.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Mei Zheng, MD, Department of Gastroenterology and Hepatology, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. zhengsm@163.com
Received: September 26, 2025
Revised: November 4, 2025
Accepted: November 25, 2025
Published online: January 27, 2026
Processing time: 117 Days and 20.9 Hours
Revised: November 4, 2025
Accepted: November 25, 2025
Published online: January 27, 2026
Processing time: 117 Days and 20.9 Hours
Core Tip
Core Tip: Castleman disease (CD) is a rare lymphoproliferative disorder. Certain variants, notably plasma cell-type CD, are associated with a potential risk of malignant transformation into lymphoma. The clinical course and prognosis of CD vary substantially across histological subtypes. Management strategies differ accordingly: Unicentric CD is generally treated with surgical excision, whereas idiopathic multicentric CD often necessitates anti–interleukin-6 monoclonal antibody and/or combination chemotherapy. We present two cases of mesenteric CD, one of which progressed to peripheral T-cell lym