Jizhi SN, Chen XY, Wu SS, Chen ZL, Liu AN, Zheng SM. Mesenteric Castleman disease: Two case reports and review of literature. World J Gastrointest Surg 2026; 18(1): 114697 [DOI: 10.4240/wjgs.v18.i1.114697]
Corresponding Author of This Article
Shu-Mei Zheng, MD, Department of Gastroenterology and Hepatology, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. zhengsm@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 27, 2026 (publication date) through Jan 28, 2026
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Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Jizhi SN, Chen XY, Wu SS, Chen ZL, Liu AN, Zheng SM. Mesenteric Castleman disease: Two case reports and review of literature. World J Gastrointest Surg 2026; 18(1): 114697 [DOI: 10.4240/wjgs.v18.i1.114697]
Se-Niu Jizhi, Department of Clinical Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Se-Niu Jizhi, Xing-Yu Chen, Shan-Shan Wu, Zhong-Lu Chen, A-Niu Liu, Shu-Mei Zheng, Department of Gastroenterology and Hepatology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China
Author contributions: Zheng SM designed the report; Jizhi SN and Chen XY collected the patient’s clinical data; Wu SS and Liu AN analyzed the radiological imaging; Chen ZL analyzed the histological and immunohistochemical images; Jizhi SN and Zheng SM wrote the paper; all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient’s relatives for the publication of this report.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Mei Zheng, MD, Department of Gastroenterology and Hepatology, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. zhengsm@163.com
Received: September 26, 2025 Revised: November 4, 2025 Accepted: November 25, 2025 Published online: January 27, 2026 Processing time: 117 Days and 20.9 Hours
Abstract
BACKGROUND
Castleman disease (CD) is a rare lymphoproliferative disorder most commonly occurring in the mediastinum and hilar regions. Mesenteric involvement is rare, and diagnosis primarily relies on histopathological examination.
CASE SUMMARY
We report two cases of mesenteric CD with gastrointestinal symptoms accompanied by weight loss. Case 1 underwent complete surgical resection of the lesion. Postoperative pathology confirmed the hyaline vascular type, and the prognosis was favorable. Case 2 also underwent complete surgical resection initially, with postoperative pathology confirming the plasma cell type. However, the disease followed an aggressive course. A second surgery was performed five months later, and postoperative pathology confirmed mesenteric peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient died postoperatively due to acute renal failure.
CONCLUSION
To our knowledge, this is the first reported case of mesenteric CD transforming into PTCL-NOS, highlighting the complexity and heterogeneity of the clinical course of mesenteric CD. These findings provide insights into the personalized treatment and clinical management of this disease.
Core Tip: Castleman disease (CD) is a rare lymphoproliferative disorder. Certain variants, notably plasma cell-type CD, are associated with a potential risk of malignant transformation into lymphoma. The clinical course and prognosis of CD vary substantially across histological subtypes. Management strategies differ accordingly: Unicentric CD is generally treated with surgical excision, whereas idiopathic multicentric CD often necessitates anti–interleukin-6 monoclonal antibody and/or combination chemotherapy. We present two cases of mesenteric CD, one of which progressed to peripheral T-cell lymphoma, highlighting the critical importance of monitoring in patients with rapid postoperative progression and the need for long-term follow-up.
