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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 110619
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.110619
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.110619
Dietary fiber as a microbiota-modulating strategy after endoscopic mucosa resection: A new frontier in postoperative care
Duygu Kirkik, Sevgi Kalkanli Tas, Department of Immunology, Hamidiye Medicine Faculty, University of Health Sciences, Istanbul 34668, Türkiye
Duygu Kirkik, Department of Medical Biology, Hamidiye Medicine Faculty, University of Health Sciences, Istanbul 34668, Türkiye
Betul Dogantekin, Internal Medicine, University of Health Sciences, Sultan 2 Abdulhamid Han Training and Research Hospital, Istanbul 34668, Türkiye
Burak Sarikaya, Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Sultan 2 Abdulhamid Han Training and Research Hospital, Istanbul 34668, Turkiye
Author contributions: Kirkik D designed the overall concept and outline of the manuscript; Dogantekin B, Kalkanli Tas S, and Sarikaya B contributed to the discussion and design of the manuscript; Kirkik D, Dogantekin B, Kalkanli Tas S, and Sarikaya B contributed to the writing, editing the manuscript, illustrations, and review of literature.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Duygu Kirkik, Assistant Professor, Department of Immunology, Hamidiye Medicine Faculty, University of Health Sciences, No. 38 Tıbbiye Cad, Mekteb-i Tıbbiye-i Şâhane (Haydarpaşa), Külliyesi Selimiye Mah, Istanbul 34668, Türkiye.
Received: June 13, 2025
Revised: July 30, 2025
Accepted: September 11, 2025
Published online: December 27, 2025
Processing time: 196 Days and 17.5 Hours
Revised: July 30, 2025
Accepted: September 11, 2025
Published online: December 27, 2025
Processing time: 196 Days and 17.5 Hours
Core Tip
Core Tip: This study highlights the novel role of dietary fiber as a microbiota-targeted therapy in patients undergoing endoscopic mucosal resection. By restoring microbial diversity and enhancing barrier integrity, fiber supplementation offers a non-invasive, immunologically informed approach to optimize postoperative recovery. The discussion findings underscore the need for precision nutrition strategies tailored to individual microbial and immune profiles to reduce complications and improve long-term gastrointestinal outcomes.