Kirkik D, Dogantekin B, Kalkanli Tas S, Sarikaya B. Dietary fiber as a microbiota-modulating strategy after endoscopic mucosa resection: A new frontier in postoperative care. World J Gastrointest Surg 2025; 17(12): 110619 [DOI: 10.4240/wjgs.v17.i12.110619]
Corresponding Author of This Article
Duygu Kirkik, Assistant Professor, Department of Immunology, Hamidiye Medicine Faculty, University of Health Sciences, No. 38 Tıbbiye Cad, Mekteb-i Tıbbiye-i Şâhane (Haydarpaşa), Külliyesi Selimiye Mah, Istanbul 34668, Türkiye. dygkirkik@gmail.com
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Gastroenterology & Hepatology
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Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 27, 2025 (publication date) through Dec 25, 2025
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Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Kirkik D, Dogantekin B, Kalkanli Tas S, Sarikaya B. Dietary fiber as a microbiota-modulating strategy after endoscopic mucosa resection: A new frontier in postoperative care. World J Gastrointest Surg 2025; 17(12): 110619 [DOI: 10.4240/wjgs.v17.i12.110619]
World J Gastrointest Surg. Dec 27, 2025; 17(12): 110619 Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.110619
Dietary fiber as a microbiota-modulating strategy after endoscopic mucosa resection: A new frontier in postoperative care
Duygu Kirkik, Betul Dogantekin, Sevgi Kalkanli Tas, Burak Sarikaya
Duygu Kirkik, Sevgi Kalkanli Tas, Department of Immunology, Hamidiye Medicine Faculty, University of Health Sciences, Istanbul 34668, Türkiye
Duygu Kirkik, Department of Medical Biology, Hamidiye Medicine Faculty, University of Health Sciences, Istanbul 34668, Türkiye
Betul Dogantekin, Internal Medicine, University of Health Sciences, Sultan 2 Abdulhamid Han Training and Research Hospital, Istanbul 34668, Türkiye
Burak Sarikaya, Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Sultan 2 Abdulhamid Han Training and Research Hospital, Istanbul 34668, Turkiye
Author contributions: Kirkik D designed the overall concept and outline of the manuscript; Dogantekin B, Kalkanli Tas S, and Sarikaya B contributed to the discussion and design of the manuscript; Kirkik D, Dogantekin B, Kalkanli Tas S, and Sarikaya B contributed to the writing, editing the manuscript, illustrations, and review of literature.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Duygu Kirkik, Assistant Professor, Department of Immunology, Hamidiye Medicine Faculty, University of Health Sciences, No. 38 Tıbbiye Cad, Mekteb-i Tıbbiye-i Şâhane (Haydarpaşa), Külliyesi Selimiye Mah, Istanbul 34668, Türkiye. dygkirkik@gmail.com
Received: June 13, 2025 Revised: July 30, 2025 Accepted: September 11, 2025 Published online: December 27, 2025 Processing time: 196 Days and 17.4 Hours
Abstract
Emerging evidence underscores the critical role of intestinal microbiota in postoperative recovery and long-term outcomes of gastrointestinal procedures. In this editorial, we comment on the retrospective study by Niu et al, which highlights the beneficial impact of dietary fiber supplementation on gut microbiota restoration following endoscopic mucosa resection. The findings highlight the potential of fiber supplementation to modulate gut microbiota and support recovery following endoscopic mucosa resection. Nonetheless, we also emphasize the need for prospective, randomized studies to delineate the optimal type, dose, and duration of fiber supplementation. This research represents a significant step toward evidence-based nutritional interventions in minimally invasive gastrointestinal surgery and underscores the importance of microbiota-targeted therapies in personalized postoperative care.
Core Tip: This study highlights the novel role of dietary fiber as a microbiota-targeted therapy in patients undergoing endoscopic mucosal resection. By restoring microbial diversity and enhancing barrier integrity, fiber supplementation offers a non-invasive, immunologically informed approach to optimize postoperative recovery. The discussion findings underscore the need for precision nutrition strategies tailored to individual microbial and immune profiles to reduce complications and improve long-term gastrointestinal outcomes.
