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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2026; 17(2): 111453
Published online Feb 15, 2026. doi: 10.4239/wjd.v17.i2.111453
Published online Feb 15, 2026. doi: 10.4239/wjd.v17.i2.111453
Integrated hepatic transcriptome and metabolome reveal the mechanisms of Jiangtang Tiaozhi formula on improving glycolipid metabolic disorder
Jia-Xing Tian, Yan-Jiao Zhang, Kai-Le Ma, Institute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Yu-Xin Zhang, Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neu
Jia-Hua Wei, Hui-Fang Guan, Graduate College, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China
Xin-Yi Fang, Hao-Ran Wu, Graduate College, Beijing University of Chinese Medicine, Beijing 100029, China
Run-Yu Miao, Department of Integrative Medicine, China-Japan Friendship Hospital, Beijing 100029, China
Xin-Miao Wang, Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Co-first authors: Jia-Xing Tian and Yan-Jiao Zhang.
Co-corresponding authors: Xin-Miao Wang and Hao-Ran Wu.
Author contributions: Tian JX and Zhang YJ contributed to conceptualization; Wang XM and Wu HR contributed to methodology; Fang XY contributed to software; Zhang YX contributed to validation and formal analysis; Ma KL contributed to investigation; Zhang YJ contributed to resources, data curation and writing original draft preparation; Tian JX contributed to writing review and editing, project administration, funding acquisition; Wei JH contributed to visualization; Miao RY and Guan HF contributed to supervision; all authors have read and agreed to the published version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 82474323; CACMS Outstanding Young Scientific and Technological Talents Program, No. ZZ13-YQ-026; High Level Chinese Medical Hospital Promotion Project, No. HLCMHPP20230CZ40907; Open Project of National Facility for Translational Medicine, No. TMSK-2021-407; and Qiushi Project of the China Association of Chinese Medicine, No. 2024-QNQS-12.
Institutional review board statement: This study does not involve any human experiments.
Institutional animal care and use committee statement: The animal study protocol was approved by the Ethics Committee of Guang’anmen Hospital, China Academy of Chinese Medical Sciences (No. IACUC-GAMH-2019–002).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets presented in this study can be found in online repositories. The names of the repository and accession number(s) can be found below: The transcriptomics data have been deposited to the PRJNA1119699 dataset (https://www.ncbi.nlm.nih.gov/sra/PRJNA1119699). Metabolomics data have been deposited to the EMBL-EBI MetaboLights database with the identifier MTBLS10385 (https://www.ebi.ac.uk/metabolights/MTBLS10385).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hao-Ran Wu, MD, Doctor, Graduate College, Beijing University of Chinese Medicine, No. 11 Beisanhuandong Road, Chaoyang Street, Beijing 100029, China.
Received: June 30, 2025
Revised: September 1, 2025
Accepted: December 8, 2025
Published online: February 15, 2026
Processing time: 221 Days and 21 Hours
Revised: September 1, 2025
Accepted: December 8, 2025
Published online: February 15, 2026
Processing time: 221 Days and 21 Hours
Core Tip
Core Tip: This study explores the effects of Jiangtang Tiaozhi formula (JTTZF) on glycolipid metabolic disorder in high-fat diet-induced mice. By integrating hepatic transcriptome and metabolome analyses, we find that JTTZF regulates key genes and metabolites linked to glucose and lipid metabolism. Our results highlight the potential of JTTZF as a therapeutic agent for glycolipid metabolic disorder and provide valuable insights into its underlying mechanisms.