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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2025; 16(10): 110211
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.110211
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.110211
Association between uric acid to high-density lipoprotein ratio and mental health symptoms in people with type 2 diabetes
Hui Xu, Department of Hospital Management, Quzhou Hospital of Traditional Chinese Medicine, Quzhou 324000, Zhejiang Province, China
Dong-Juan He, Xian-Mei Yu, Department of Endocrinology, The Second People’s Hospital of Quzhou, Quzhou 324002, Zhejiang Province, China
Cheng Luo, Cheng-Zheng Duan, Department of Endocrinology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang Province, China
Da Sun, Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou 325000, Zhejiang Province, China
De-Jun Wu, Xiao-Qiang Mao, Wei-Feng Jiang, Department of Gerontology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China
Co-first authors: Hui Xu and Dong-Juan He.
Author contributions: Xu H and He DJ contributed to writing - original draft and contributed equally as co-first authors; He DJ, Sun D, and Jiang WF contributed to writing - review & editing; Xu H, Luo C, Duan CZ, and Mao XQ contributed to investigation, methodology, software; Xu H, Duan CZ, Wu DJ, and Mao XQ contributed to data curation; Xu H, Luo C, Sun D, and Jiang WF contributed to formal analysis; Luo C, Yu XM, Duan CZ, and Mao XQ contributed to validation; Xu H, Yu XM, Duan CZ, and Sun D contributed to visualization; He DJ and Jiang WF contributed to funding acquisition, project administration, resources, supervision; All authors contributed to conceptualization.
Supported by Science and Technology Program of Quzhou, China, No. 2022K67; Zhejiang Medical Association Clinical Research Fund Project, No. 2024ZYC-A526; and the Research Project of Quzhou People’s Hospital, No. KYQD2024-006.
Institutional review board statement: This study was approved by the Ethics Committee of the Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital (Approval No. 2022-133). All procedures involving human participants were conducted in accordance with the ethical standards of the institutional and national research committees and with the 1964 Helsinki Declaration and its later amendments.
Informed consent statement: Written informed consent was obtained from all participants after they were fully informed of the study objectives, procedures, potential risks, and benefits. Participation was entirely voluntary.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest related to this study.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised accordingly.
Data sharing statement: The raw data supporting the conclusions of this study will be made available by the corresponding author upon reasonable request, without undue reservation.
Open Access: This article is an open-access article that was selected by an in-house editor and was fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Feng Jiang, MD, Associate Chief Physician, Department of Gerontology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, No. 100 Minjiang Avenue, Kecheng District, Quzhou 324000, Zhejiang Province, China. weifengjiang@wmu.edu.cn
Received: June 3, 2025
Revised: July 2, 2025
Accepted: August 18, 2025
Published online: October 15, 2025
Processing time: 136 Days and 22.4 Hours
Revised: July 2, 2025
Accepted: August 18, 2025
Published online: October 15, 2025
Processing time: 136 Days and 22.4 Hours
Core Tip
Core Tip: This study highlights the significant association between the uric acid-to-high-density lipoprotein cholesterol ratio (UHR) and symptoms of depression and anxiety in individuals with type 2 diabetes mellitus (T2DM). Using multivariate and nonlinear analyses, the study identifies threshold effects, suggesting that elevated UHR levels may serve as a cost-effective biomarker for psychological distress in T2DM. These findings underscore the importance of integrating metabolic and mental health assessments in diabetic care, particularly in high-risk subgroups.