Jadzic JS, Kekovic VD. Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes. World J Diabetes 2025; 16(12): 114003 [DOI: 10.4239/wjd.v16.i12.114003]
Corresponding Author of This Article
Jelena S Jadzic, MD, PhD, Post Doctoral Researcher, Assistant Professor, Center of Bone Biology, Faculty of Medicine, University of Belgrade, Dr. Subotica 4/2, Belgrade 11000, Serbia. jelena.jadzic@med.bg.ac.rs
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Endocrinology & Metabolism
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Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 15, 2025 (publication date) through Dec 15, 2025
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World Journal of Diabetes
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1948-9358
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Jadzic JS, Kekovic VD. Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes. World J Diabetes 2025; 16(12): 114003 [DOI: 10.4239/wjd.v16.i12.114003]
World J Diabetes. Dec 15, 2025; 16(12): 114003 Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.114003
Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes
Jelena S Jadzic, Vladan D Kekovic
Jelena S Jadzic, Center of Bone Biology, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia
Vladan D Kekovic, Department of Maxillofacial Surgery, Faculty of Dental Medicine, University of Belgrade, Belgrade 11000, Serbia
Author contributions: Jadzic JS contributed to conceiving the study, conducting the literature search, data visualization, and writing the original draft of the manuscript; Kekovic VD contributed to reviewing and editing the manuscript; All authors approved the submitted version of the manuscript.
Supported by the Ministry of Science of the Republic of Serbia, No. 451-03-4551/2024-04/18 and No. 451-03-137/2025-03/200110.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jelena S Jadzic, MD, PhD, Post Doctoral Researcher, Assistant Professor, Center of Bone Biology, Faculty of Medicine, University of Belgrade, Dr. Subotica 4/2, Belgrade 11000, Serbia. jelena.jadzic@med.bg.ac.rs
Received: September 9, 2025 Revised: October 10, 2025 Accepted: October 27, 2025 Published online: December 15, 2025 Processing time: 97 Days and 9.6 Hours
Abstract
We read with great interest the article by Li et al, reporting an observational study on the inflammatory response-mediated bone loss after dental implant surgery in patients with type 2 diabetes mellitus (T2DM). This study provides relevant information for reducing the risk of peri-implantitis after dental implant surgery in T2DM, highlighting the need to bridge the gap between risk identification and effective clinical management. However, the complex etiopathogenetic mechanisms elucidating the association between elevated inflammatory response markers and marginal bone loss in T2DM are not sufficiently clarified. Recent studies suggest that perirenal adipose tissue and alcohol consumption affect bone metabolism, which may contribute to the observed marginal bone loss after dental implant surgery in T2DM. Therefore, further studies using state-of-the-art bone-assessing methodologies are needed to enhance our understanding of the potential covariant effects of perirenal adipose tissue and alcohol consumption on inflammatory response-mediated bone loss after dental implant surgery in T2DM.
Core Tip: The observational study by Li et al assessed the inflammatory response after dental implant surgery in patients with type 2 diabetes mellitus (T2DM). While this study is clinically relevant, the mechanisms elucidating the association between elevated inflammatory markers and marginal bone loss in T2DM are scarcely described. Perirenal adipose tissue secreted adipokines and alcohol consumption may contribute to marginal peri-implant bone alterations in T2DM. Therefore, further studies are needed to assess potential covariant effects of perirenal fat and alcohol consumption on inflammatory response-mediated bone loss after dental implant surgery in patients with T2DM.
