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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2025; 16(12): 114003
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.114003
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.114003
Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes
Jelena S Jadzic, Center of Bone Biology, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia
Vladan D Kekovic, Department of Maxillofacial Surgery, Faculty of Dental Medicine, University of Belgrade, Belgrade 11000, Serbia
Author contributions: Jadzic JS contributed to conceiving the study, conducting the literature search, data visualization, and writing the original draft of the manuscript; Kekovic VD contributed to reviewing and editing the manuscript; All authors approved the submitted version of the manuscript.
Supported by the Ministry of Science of the Republic of Serbia, No. 451-03-4551/2024-04/18 and No. 451-03-137/2025-03/200110.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jelena S Jadzic, MD, PhD, Post Doctoral Researcher, Assistant Professor, Center of Bone Biology, Faculty of Medicine, University of Belgrade, Dr. Subotica 4/2, Belgrade 11000, Serbia. jelena.jadzic@med.bg.ac.rs
Received: September 9, 2025
Revised: October 10, 2025
Accepted: October 27, 2025
Published online: December 15, 2025
Processing time: 97 Days and 9.6 Hours
Revised: October 10, 2025
Accepted: October 27, 2025
Published online: December 15, 2025
Processing time: 97 Days and 9.6 Hours
Core Tip
Core Tip: The observational study by Li et al assessed the inflammatory response after dental implant surgery in patients with type 2 diabetes mellitus (T2DM). While this study is clinically relevant, the mechanisms elucidating the association between elevated inflammatory markers and marginal bone loss in T2DM are scarcely described. Perirenal adipose tissue secreted adipokines and alcohol consumption may contribute to marginal peri-implant bone alterations in T2DM. Therefore, further studies are needed to assess potential covariant effects of perirenal fat and alcohol consumption on inflammatory response-mediated bone loss after dental implant surgery in patients with T2DM.