Neutrophil-albumin ratio and multi-phase computed tomography for lymph node metastasis in pancreatic cancer

Table 1 Comparison of baseline data

Grouping	LNM+ group (n = 61)	LNM- group (n = 68)	t/χ2	P value
Age (years)	60.13 ± 8.58	55.30 ± 9.70	2.295	0.023
Gender			2.628	0.105
Male	40 (65.57)	35 (51.47)
Female	21 (34.43)	33 (48.53)
BMI (kg/m2)			1.844	0.174
≤ 24	36 (59.02)	32 (47.06)
> 24	25 (40.98)	36 (52.94)
Hemangioma thrombosis			6.387	0.011
Have	36 (59.02)	25 (36.76)
None	25 (40.98)	43 (63.24)
Tumor size (cm)	3.82 ± 1.07	3.43 ± 1.13	2.001	0.048
Tumor location			0.833	0.361
Head of pancreas	49 (80.33)	50 (73.53)
Body/tail of pancreas	12 (19.67)	18 (26.47)
Pathological type			3.703	0.157
PDAC	57 (93.44)	56 (82.35)
IPMT	2 (3.28)	5 (7.35)
PNEC	2 (3.28)	7 (10.29)
CA19-9 (U/mL)			0.490	0.484
≤ 37	18 (29.51)	24 (35.29)
> 37	43 (70.49)	44 (64.71)
CEA (U/mL)			0.944	0.331
≤ 5	47 (77.05)	57 (83.82)
> 5	14 (22.95)	11 (16.18)
PAR			8.495	0.004
≤ 6.35	22 (36.07)	42 (61.76)
> 6.35	39 (63.93)	26 (38.24)
NAR			18.710	< 0.001
≤ 0.13	18 (29.51)	46 (67.65)
> 0.13	43 (70.49)	22 (32.35)
CT report of lymph node status			15.364	< 0.001
Lymph nodes (+)	37 (60.66)	18 (26.47)
Lymph nodes (-)	24 (39.34)	50 (73.53)
CT report T status			1.669	0.434
T1	6 (9.84)	11 (16.18)
T2	34 (55.74)	39 (57.35)
T3	21 (34.42)	18 (26.47)

Data were showed as n (%) or mean ± SD. LNM: Lymph node metastasis; BMI: Body mass index; PDAC: Pancreatic ductal adenocarcinoma; IPMT: Intraductal papillary mucinous tumor; PNEC: Pulmonary neuroendocrine cells; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; PAR: Platelet-albumin ratio; NAR: Neutrophil-albumin ratio; CT: Computed tomography.

Table 2 Univariate Logistic regression analysis

Variable	β	SE	Wald	OR (95%CI)	P value
Age	0.018	0.025	0.557	1.019 (0.970-1.069)	0.455
Tumor size	0.399	0.209	3.659	1.490 (0.990-2.242)	0.056
Hemangioma thrombosis	1.322	0.465	8.086	3.751 (1.508-9.330)	0.004
PAR > 6.35	1.593	0.490	10.544	4.917 (1.880-12.857)	0.001
NAR > 0.13	1.447	0.459	9.925	4.250 (1.728-10.456)	0.002
CT report lymph nodes (+)	1.637	0.470	12.137	5.141 (2.046-12.913)	< 0.001
Constant	-5.491	1.709	10.324	0.004	0.001

PAR: Platelet-albumin ratio; NAR: Neutrophil-albumin ratio; CT: Computed tomography.

Table 3 Multivariate Logistic regression analysis

Variable	β	SE	Wald	OR (95%CI)	P value
Hemangioma thrombosis	1.219	0.450	7.326	3.383 (1.400-8.177)	0.007
PAR > 6.35	1.585	0.468	11.493	4.880 (1.952-12.202)	0.001
NAR > 0.13	1.509	0.437	11.919	4.521 (1.920-10.647)	0.001
CT report lymph nodes (+)	1.679	0.462	13.198	5.361 (2.167-13.265)	< 0.001
Constant	-2.991	0.579	26.646	0.050	< 0.001

PAR: Platelet-albumin ratio; NAR: Neutrophil-albumin ratio; CT: Computed tomography.

Table 4 Receiver operating characteristic curve results

Variable	AUC	Youden index	Optimal cutoff value	Sensitivity (%)	Specificity (%)	95%CI	P value
Hemangioma thrombosis	0.611	0.223	1	59.02	63.24	0.521-0.696	< 0.001
PAR > 6.35	0.628	0.257	1	63.93	61.76	0.539-0.712	0.003
NAR > 0.13	0.691	0.381	1	70.49	67.65	0.603-0.769	< 0.001
CT report lymph nodes (+)	0.671	0.342	1	60.66	73.53	0.583-0.751	< 0.001
Model 1	0.758	0.402	0.511	47.54	92.65	0.675-0.829	< 0.001
Model 2	0.690	0.304	0.491	37.70	92.65	0.602-0.768	< 0.001
Model 3	0.830	0.512	0.435	83.61	67.65	0.753-0.890	< 0.001

AUC: Area under the curve; PAR: Platelet-albumin ratio; NAR: Neutrophil-albumin ratio; CT: Computed tomography.