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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2025; 17(12): 113879
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113879
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113879
Neutrophil-albumin ratio and multi-phase computed tomography for lymph node metastasis in pancreatic cancer
Huan Wang, Fang Zhang, Department of Imaging, Ordos Central Hospital, Ordos 017000, Inner Mongolia Autonomous Region, China
Tian-Yu Fu, Department of Cardio-Thoracic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming 650032, Yunnan Province, China
Fei-Chao Kang, Medical Imaging Center, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China
Zhong-Wei Sun, Surgery of Vascular and Abdominal Hernia, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China
Co-first authors: Huan Wang and Tian-Yu Fu.
Author contributions: Wang H and Fu TY contribute equally to this study as co-first authors; Wang H, Fu TY, Zhang F and Kang FC contributed to research design, data collection, data analysis, and paper writing; Sun ZW was responsible for research design, funding application, data analysis, reviewing and editing, communication coordination, ethical review, copyright and licensing, and follow-up.
Institutional review board statement: The study was reviewed and approved by the Ordos Central Hospital Institutional Review Board, No. 2025-402.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: No conflict of interest is associated with this work.
Data sharing statement: No other data available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhong-Wei Sun, PhD, Surgery of Vascular and Abdominal Hernia, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian 116001, Liaoning Province, China. go904013705@163.com
Received: September 9, 2025
Revised: October 11, 2025
Accepted: November 6, 2025
Published online: December 15, 2025
Processing time: 93 Days and 0.4 Hours
Revised: October 11, 2025
Accepted: November 6, 2025
Published online: December 15, 2025
Processing time: 93 Days and 0.4 Hours
Core Tip
Core Tip: For the first time, we integrated systemic inflammation-nutrition indices [neutrophil-albumin ratio (NAR), platelet-albumin ratio (PAR)] with multi-phase computed tomography (CT) radiomics to predict lymph node metastasis of pancreatic cancer. The resulting four-marker model (NAR > 0.13, PAR > 6.35, hemangioma thrombosis, CT-positive nodes) achieved an area under the curve of 0.830, surpassing conventional imaging and offering a cost-free, pre-operative tool for personalized surgical planning and neoadjuvant selection.