Epidemiologic characteristics and risk factors associated with overall survival for patients with mucinous colorectal cancer: A population-based study

Table 1 Baseline clinicopathological characteristics of mucinous colorectal adenocarcinoma

Variable	n	% among 45481 total
Age in yr
15-39	1865	4.1
40-54	7816	17.2
55-69	14499	31.9
≥ 70	21301	46.8
Sex
Male	21976	48.3
Female	23505	51.7
Race
White	37134	81.6
Black	5099	11.2
Asian or Pacific Islander	2865	6.3
American Indian and Alaska Native	249	0.5
Unknown	134	0.3
Marital status
Single	6476	14.2
Married	24100	53.0
Other1	14905	32.8
Tumor site
Proximal colon	20714	45.5
Transverse colon	3510	7.7
Distal colon	11065	24.3
Rectum	5149	11.3
Appendix	3572	7.9
Large intestine, unspecified	1471	3.2
Grade2
1	5051	11.1
2	25253	55.5
3	7703	16.9
4	963	2.1
Unknown	6511	14.3
Disease stage
In situ	2	0.0
Localized	11973	26.3
Regional	21436	47.1
Distant	11407	25.1
Unknown/unstaged	663	1.5
Surgery
Yes	41667	91.6
No/Unknown	3814	8.4
Radiation
Yes	4865	10.7
No/Unknown	40616	89.3
Chemotherapy
Yes	19199	42.2
No/Unknown	26282	57.8

¹Separated, divorced, widowed, or unknown marital status; ²I: Well differentiated, II: Moderately differentiated, III: Poorly differentiated, and IV: Undifferentiated.

Table 2 Univariate and multivariate Cox regression analyses of predictive factors associated with overall survival in mucinous adenocarcinoma

Variables	Subgroup	Univariable		Multivariable
		Hazard ratio	P value	Hazard ratio	P value
Age in yr	< 40	Reference	< 0.001	Reference	< 0.001
	40-69	1.15 (0.90-1.46)		1.28 (1.00-1.64)
	≥ 70	1.85 (1.45-2.35)		2.41 (1.88-3.08)
Sex	Male	Reference	0.211	/
	Female	1.06 (0.97-1.15)
Race	White	Reference	0.035	Reference	< 0.001
	Black	1.15 (1.02-1.30)		1.26 (1.11-1.43)
	Other1	0.90 (0.75-1.08)		0.92 (0.77-1.10)
Tumor site	Proximal colon	Reference	< 0.001	Reference	< 0.001
	Transverse colon	0.93 (0.79-1.09)		0.88 (0.75-1.04)
	Distal colon	1.17 (1.05-1.29)		1.15 (1.04-1.28)
	Rectum	0.92 (0.79-1.08)		1.14 (0.97-1.34)
	Appendix	0.74 (0.61-0.88)		0.58 (0.47-0.72)
Tumor size	≤ 30	Reference	< 0.001	Reference	0.625
	31-59	1.41 (1.24-1.61)		1.06 (0.92-1.22)
	≥ 60	1.57 (1.38-1.79)		1.07 (0.93-1.23)
Grade	I	Reference	< 0.001	Reference	0.073
	II	1.20 (1.04-1.39)		1.11 (0.95-1.30)
	III	1.71 (1.45-2.02)		1.23 (1.03-1.46)
	IV	2.07 (1.67-2.57)		1.26 (1.01-1.58)
Disease stage	Localized	Reference	< 0.001	Reference	0.105
	Regional	1.49 (1.33-1.67)		0.90 (0.77-1.06)
	Distant	4.32 (3.83-4.88)		1.16 (0.85-1.60)
T stage	T1	Reference	< 0.001	Reference	< 0.001
	T2	0.86 (0.63-1.16)		0.99 (0.72-1.35)
	T3	1.41 (1.08-1.85)		1.37 (1.03-1.83)
	T4	2.67 (2.03-3.50)		2.28 (1.68-3.08)
N stage	N0	Reference	< 0.001	Reference	< 0.001
	N1	1.63 (1.47-1.81)		1.72 (1.51-1.97)
	N2	2.90 (2.62-3.21)		2.58 (2.25-2.96)
M stage	M0	Reference	< 0.001	Reference	< 0.001
	M1	3.75 (3.42-4.11)		2.67 (2.01-3.55)
Surgery	Yes	Reference	< 0.001	Reference	< 0.001
	No/Unknown	5.08 (3.83-6.73)		4.82 (3.57-6.51)
Radiation	Yes	Reference	0.764	/
	No/Unknown	1.02 (0.89-1.17)
Chemotherapy	Yes	Reference	< 0.001	Reference	< 0.001
	No/Unknown	0.87 (0.80-0.95)		1.58 (1.42-1.76)

¹Defined as the Asian/Pacific Islander and American Indian/Alaska Native.