Jiang J, Tang XW, Huang S, Hu N, Chen Y, Luo B, Ren WS, Peng Y, Yang WX, Lü MH. Epidemiologic characteristics and risk factors associated with overall survival for patients with mucinous colorectal cancer: A population-based study. World J Gastrointest Oncol 2023; 15(8): 1461-1474 [PMID: 37663939 DOI: 10.4251/wjgo.v15.i8.1461]
Corresponding Author of This Article
Mu-Han Lü, MD, PhD, Full Professor, Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou 646099, Sichuan Province, China. lvmuhan@swmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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Jiang J, Tang XW, Huang S, Hu N, Chen Y, Luo B, Ren WS, Peng Y, Yang WX, Lü MH. Epidemiologic characteristics and risk factors associated with overall survival for patients with mucinous colorectal cancer: A population-based study. World J Gastrointest Oncol 2023; 15(8): 1461-1474 [PMID: 37663939 DOI: 10.4251/wjgo.v15.i8.1461]
World J Gastrointest Oncol. Aug 15, 2023; 15(8): 1461-1474 Published online Aug 15, 2023. doi: 10.4251/wjgo.v15.i8.1461
Epidemiologic characteristics and risk factors associated with overall survival for patients with mucinous colorectal cancer: A population-based study
Jiao Jiang, Xiao-Wei Tang, Shu Huang, Nan Hu, Yuan Chen, Bei Luo, Wen-Sen Ren, Yan Peng, Wei-Xing Yang, Mu-Han Lü
Jiao Jiang, Xiao-Wei Tang, Nan Hu, Yuan Chen, Bei Luo, Wen-Sen Ren, Yan Peng, Wei-Xing Yang, Mu-Han Lü, Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, Luzhou 646099, Sichuan Province, China
Shu Huang, Department of Gastroenterology, the People’s Hospital of Lianshui, Huaian 223400, Jiangsu Province, China
Author contributions: Jiang J, Tang XW, and Huang S contributed equally to this work; Luo B, Hu N, Tang XW, and Chen Y designed the research study; Ren WS and Jiang J performed the data extraction; Jiang J, Tang XW, and Huang S analyzed the data and wrote the manuscript; Peng Y, Yang WX, and Lü MH revised the manuscript; All authors read and approved the final manuscript.
Supported byScience & Technology Department of Sichuan Province, No. 2021JDTD0003; and Scientific Research Cooperation Project of Suining First People’s Hospital and the Affiliated Hospital of Southwest Medical University, No. 2021SNXNYD05.
Institutional review board statement: This research project falls under the category of research conducted using lawfully obtained public data or data generated through observation without interfering with public behavior. Review and informed consent were exempted.
Informed consent statement: All data were downloaded from the “SEER Database,” and informed consents were exempted.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: No additional data are available.
Corresponding author: Mu-Han Lü, MD, PhD, Full Professor, Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou 646099, Sichuan Province, China. lvmuhan@swmu.edu.cn
Received: April 17, 2023 Peer-review started: April 17, 2023 First decision: May 4, 2023 Revised: May 21, 2023 Accepted: June 13, 2023 Article in press: June 13, 2023 Published online: August 15, 2023 Processing time: 115 Days and 0.2 Hours
ARTICLE HIGHLIGHTS
Research background
Mucinous adenocarcinoma (MC) is a distinct histologic subtype of colorectal cancer (CRC), which differs from nonmucinous CRC in terms of clinicopathological characteristics and genetic features.
Research motivation
There are limited data about epidemiologic characteristics of MC, and little is known about the risk factors associated with the survival rates.
Research objectives
In this study, we aimed to determine the epidemiologic and clinicopathological characteristics of mucinous CRC.
Research methods
We conducted a population-based analysis of the epidemiologic and clinicopathological characteristics of mucinous CRC on the basis of data extracted from the National Cancer Institute’s Surveillance, Epidemiology, and End Results Program.
Research results
Rates of mucinous CRC decreased from 4.50/100000 in 2000 to 1.54/100000 in 2018. Rates of mucinous CRCs in patients aged ≤ 50 years decreased 2.27%/year during 2000-2018, in sharp contrast to the upward trend in early-onset CRC. Incidence of appendiceal MCs increased from 0.14/100000 in 2000 to 0.24/100000 in 2018. On multivariable Cox analyses, age, race, tumor site, T stage, N stage, M stage, surgery, and chemotherapy were associated with overall survival. A nomogram was developed based on these factors, and the area under the curve for 1-year, 3-year, and 5-year overall survival in the training cohort was 0.778, 0.778 and 0.768, respectively, and was 0.805, 0.779 and 0.760 in the validation cohort, respectively.
Research conclusions
We found that the incidence of mucinous CRC decreased both in young and older patients. However, the incidence of appendiceal MCs continued to increase. During the survival analysis, in addition to the TNM tumor stages, we found that age, race, tumor site, surgery, and chemotherapy were also significantly associated with survival. A nomogram based on these factors as well as the T, N, and M stages showed a good predictive performance.
Research perspectives
We laid a foundation for future research exploring the prognostic implications of mucinous colorectal adenocarcinoma.
