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World J Gastrointest Oncol. Jul 15, 2026; 18(7): 118256
Published online Jul 15, 2026. doi: 10.4251/wjgo.v18.i7.118256
Published online Jul 15, 2026. doi: 10.4251/wjgo.v18.i7.118256
Novel regulatory network of PS-1/β-catenin/p-PTEN axis in gastric cancer invasion
Shuai Xiao, Dan-Dan Song, Ye-Ping Yu, Xiao-Zhen Xu, Jing-Feng Tang, Ce-Fan Zhou, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, Hubei Province, China
Shuai Xiao, Henan Key Laboratory of Tea Plant Biology, College of Tea and Food Science, Xinyang Normal University, Xinyang 464000, Henan Province, China
Co-first authors: Shuai Xiao and Dan-Dan Song.
Author contributions: Xiao S and Song DD prepared the original draft and they contributed equally to this manuscript as co-first authors; Zhou CF and Tang JF contributed to the conceptualization, writing, review, and editing of the manuscript; Xu XZ and Yu YP collaboratively drafted the manuscript. All authors have reviewed and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 32571378, No. 32270768, No. 82273970, No. U25A20650, and No. 82370715; the Key Cultivation Project of Hubei Province for Science and Technology, No. 2024DJA037; and National Natural Science Foundation of Hubei, No. 2025AFA085.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Ce-Fan Zhou, PhD, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China.
Received: December 28, 2025
Revised: January 22, 2026
Accepted: April 9, 2026
Published online: July 15, 2026
Processing time: 191 Days and 10.1 Hours
Revised: January 22, 2026
Accepted: April 9, 2026
Published online: July 15, 2026
Processing time: 191 Days and 10.1 Hours
Core Tip
Core Tip: Gastric cancer (GC) is a type of malignant tumor with high mortality and morbidity rates. Tumor metastasis and recurrence are among the main causes of death for GC patients, yet the specific mechanisms behind them remain unclear. This paper comments on a recent study that revealed the regulatory correlation among presenilin-1, β-catenin, and phosphorylated phosphatase and tensin homolog in GC and their combined role in GC cell invasion.