Xiao S, Song DD, Yu YP, Xu XZ, Tang JF, Zhou CF. Novel regulatory network of PS-1/β-catenin/p-PTEN axis in gastric cancer invasion. World J Gastrointest Oncol 2026; 18(7): 118256 [DOI: 10.4251/wjgo.v18.i7.118256]
Corresponding Author of This Article
Ce-Fan Zhou, PhD, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
review-article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Shuai Xiao, Dan-Dan Song, Ye-Ping Yu, Xiao-Zhen Xu, Jing-Feng Tang, Ce-Fan Zhou, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, Hubei Province, China
Shuai Xiao, Henan Key Laboratory of Tea Plant Biology, College of Tea and Food Science, Xinyang Normal University, Xinyang 464000, Henan Province, China
Co-first authors: Shuai Xiao and Dan-Dan Song.
Author contributions: Xiao S and Song DD prepared the original draft and they contributed equally to this manuscript as co-first authors; Zhou CF and Tang JF contributed to the conceptualization, writing, review, and editing of the manuscript; Xu XZ and Yu YP collaboratively drafted the manuscript. All authors have reviewed and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 32571378, No. 32270768, No. 82273970, No. U25A20650, and No. 82370715; the Key Cultivation Project of Hubei Province for Science and Technology, No. 2024DJA037; and National Natural Science Foundation of Hubei, No. 2025AFA085.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Ce-Fan Zhou, PhD, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Received: December 28, 2025 Revised: January 22, 2026 Accepted: April 9, 2026 Published online: July 15, 2026 Processing time: 191 Days and 9.2 Hours
Abstract
Gastric cancer (GC) is the fifth most prevalent malignancy globally, characterized by abnormal mutant genes, high heterogeneity, and poor prognosis. A recent study focused on the expression, regulatory relationships, and effects on cell invasion of presenilin-1 (PS-1), β-catenin, and phosphorylated phosphatase and tensin homolog (p-PTEN) in GC. This study is the first integration of the tripartite regulatory network involving PS-1, β-catenin, and p-PTEN in GC. It revealed that PS-1 serves as a novel regulatory component that modulates p-PTEN through β-catenin-mediated mechanisms, thereby facilitating GC cell invasion. While this study provides valuable insights, several limitations should be noted: (1) The exclusive use of the MGC-803 cell line may not fully capture the biological diversity across different GC molecular subtypes; and (2) The precise molecular mechanisms underlying the interaction between PS-1 and β-catenin remain to be elucidated. Nevertheless, these findings significantly advance our understanding of GC metastasis mechanisms and substantiate the potential therapeutic value of targeting PS-1, β-catenin, and p-PTEN in GC treatment.
Core Tip: Gastric cancer (GC) is a type of malignant tumor with high mortality and morbidity rates. Tumor metastasis and recurrence are among the main causes of death for GC patients, yet the specific mechanisms behind them remain unclear. This paper comments on a recent study that revealed the regulatory correlation among presenilin-1, β-catenin, and phosphorylated phosphatase and tensin homolog in GC and their combined role in GC cell invasion.
