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World J Gastrointest Oncol. May 15, 2026; 18(5): 116881
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116881
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116881
Inhibiting exosomal miR-191 can induce ferroptosis in macrophages, thereby delaying the progression of colorectal cancer
Zi-Wei Wang, Li Jia, Ling-Ke Qu, Guo-Hua Gong, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
Author contributions: Wang ZW and Jia L wrote the manuscript; Qu LK revised the language; Gong GH conceived the idea and revised the manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Guo-Hua Gong, MD, Professor, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, No. 82 West College Road, Wenzhou 325035, Zhejiang Province, China. guohgong@wmu.edu.cn
Received: November 24, 2025
Revised: January 12, 2026
Accepted: February 11, 2026
Published online: May 15, 2026
Processing time: 172 Days and 1.4 Hours
Revised: January 12, 2026
Accepted: February 11, 2026
Published online: May 15, 2026
Processing time: 172 Days and 1.4 Hours
Core Tip
Core Tip: Inhibiting miR-191 effectively suppresses macrophage M2 polarization by inducing the production of reactive oxygen species in colorectal cancer cells, triggering ferroptosis and subsequent apoptosis. Exosomal miR-191 may become a potential therapeutic target with significant implications for achieving precise diagnosis, precise treatment, and early disease prevention.