AlQattan AS, Binkhamis L, Foula MS, Alsalim A, Alselwi WM, Alzahir AA. Triple gastrointestinal malignancies with tumor-to-tumor metastasis from gastric adenocarcinoma to small bowel adenocarcinoma: A case report. World J Gastrointest Oncol 2026; 18(4): 115614 [DOI: 10.4251/wjgo.v18.i4.115614]
Corresponding Author of This Article
Lujain Binkhamis, Chief Physician, Department of Surgery, King Fahad Hospital of The University, Imam Abdulrahman Bin Faisal University, King Faisal Streat, Khobar 32232, Saudi Arabia. binkhamis.lujain@gamil.com
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Oncology
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Case Report
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Apr 15, 2026 (publication date) through Apr 11, 2026
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Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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AlQattan AS, Binkhamis L, Foula MS, Alsalim A, Alselwi WM, Alzahir AA. Triple gastrointestinal malignancies with tumor-to-tumor metastasis from gastric adenocarcinoma to small bowel adenocarcinoma: A case report. World J Gastrointest Oncol 2026; 18(4): 115614 [DOI: 10.4251/wjgo.v18.i4.115614]
World J Gastrointest Oncol. Apr 15, 2026; 18(4): 115614 Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115614
Triple gastrointestinal malignancies with tumor-to-tumor metastasis from gastric adenocarcinoma to small bowel adenocarcinoma: A case report
Abdullah Saleh AlQattan, Lujain Binkhamis, Mohammed S Foula, Alaa Alsalim, Waleed Mohammed Alselwi, Ali Ahmad Alzahir
Abdullah Saleh AlQattan, Ali Ahmad Alzahir, Department of Surgery, King Fahad Specialist Hospital, Dammam 32253, Ash Sharqīyah, Saudi Arabia
Lujain Binkhamis, Mohammed S Foula, Department of Surgery, King Fahad Hospital of The University, Imam Abdulrahman Bin Faisal University, Khobar 34446, Saudi Arabia
Alaa Alsalim, Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam 32253, Ash Sharqīyah, Saudi Arabia
Waleed Mohammed Alselwi, Department of Medical Oncology, King Fahad Specialist Hospital, Dammam 32253, Ash Sharqīyah, Saudi Arabia
Author contributions: ALQattan AS, Binkhamis L contributed equally to the conception, writing, and revision of the manuscript; Foula MS, Alsalim A, Alselwi WM and Alzahir AA contributed to manuscript revision. All authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case report and accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Lujain Binkhamis, Chief Physician, Department of Surgery, King Fahad Hospital of The University, Imam Abdulrahman Bin Faisal University, King Faisal Streat, Khobar 32232, Saudi Arabia. binkhamis.lujain@gamil.com
Received: October 27, 2025 Revised: December 23, 2025 Accepted: February 10, 2026 Published online: April 15, 2026 Processing time: 165 Days and 23.1 Hours
Core Tip
Core Tip: Metastatic involvement of the small intestine usually results from direct invasion by adjacent organs, while hematogenous spread is rare. Interestingly, metastatic tumors are more common than primary small bowel malignancies due to protective mucosal and immunological factors. Tumor-to-tumor metastasis is an exceptionally rare event, defined as the growth of a metastatic tumor within another primary neoplasm. Among reported cases, renal cell carcinoma is the most frequent recipient, and gastric primaries are exceedingly uncommon. This report presents the first documented case of Recurrent gastric adenocarcinoma metastasizing into a primary small bowel adenocarcinoma, highlighting the importance of thorough histopathological evaluation.
