Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Apr 15, 2026; 18(4): 115485
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115485
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115485
Integration of the PIPOST model with early enteral nutrition to enhance postoperative rehabilitation in colorectal cancer patients
Xiao-Mei Chang, Department of Anorectal Surgery, Ya’an People’s Hospital, Ya’an 625000, Sichuan Province, China
Xiao-Mei Chang, Faculty of Nursing, Khon Kaen University, Khon Kaen 40002, Thailand
Bing-Hua Cai, Department of General Surgery, Rudong People’s Hospital, Nantong 226400, Jiangsu Province, China
Hai-Bin Zheng, Department of General Surgery, Putuo Renji Hospital, Zhoushan 316100, Zhejiang Province, China
Co-first authors: Xiao-Mei Chang and Bing-Hua Cai.
Author contributions: Chang XM and Cai BH contributed to research design, data collection, data analysis, and paper writing, and they contributed equally to this article as co-first authors; Zheng HB was responsible for research design, funding application, manuscript review and editing, communication coordination, ethical review, copyright and licensing, and follow-up.
Institutional review board statement: The research was reviewed and approved by the Institutional Review Board of Rudong People’s Hospital, No. 2025-502.
Clinical trial registration statement: This study has not yet been registered in a clinical trials registry.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No other data available.
Corresponding author: Hai-Bin Zheng, Associate Chief Physician, Department of General Surgery, Putuo Renji Hospital, No. 90 Gongxia Road, Putuo District, Zhoushan 316100, Zhejiang Province, China. 13706809729@163.com
Received: November 4, 2025
Revised: December 5, 2025
Accepted: January 20, 2026
Published online: April 15, 2026
Processing time: 154 Days and 23.2 Hours
Revised: December 5, 2025
Accepted: January 20, 2026
Published online: April 15, 2026
Processing time: 154 Days and 23.2 Hours
Core Tip
Core Tip: This article demonstrates that implementing a structured PIPOST model for early enteral nutrition in post-colorectal cancer surgery patients significantly enhances recovery. Compared to conventional early enteral nutrition, the PIPOST-guided approach led to marked improvements in nutritional biomarkers (albumin, prealbumin, and transferrin), immune function (CD4+/CD8+ ratio and natural killer cell activity), and gastrointestinal recovery, while reducing complication rates and shortening hospital stays. This study provides evidence for a systematic and precise nutritional support framework in postoperative care.