Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Mar 15, 2026; 18(3): 116677
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.116677
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.116677
Cryoablation in locally advanced pancreatic cancer: A promising ablative frontier
Safa Kürşat Nural, Department of General Surgery, Necip Fazil City Hospital, Kahramanmaraş 46050, Türkiye
Eda Şahingöz, Department of General Surgery, University of Health Sciences, Ankara 06100, Türkiye
Mesut Tez, Department of Surgery, University of Health Sciences, Ankara City Hospital, Ankara 06800, Türkiye
Author contributions: Nural SK was responsible for visualization, writing review and editing; Şahingöz E was responsible for methodology and writing original draft; Tez M was responsible for conceptualization, data curation and supervision; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Corresponding author: Safa Kürşat Nural, MD, Department of General Surgery, Necip Fazil City Hospital, Kahramanmaraş Necip Fazıl Şehir Hastanesi Gaziantep Yolu 12 km Karacasu Kırım Mah Dulkadiroğlu, Kahramanmaraş 46050, Türkiye. dr.safakn@gmail.com
Received: November 18, 2025
Revised: December 8, 2025
Accepted: January 6, 2026
Published online: March 15, 2026
Processing time: 114 Days and 17.5 Hours
Revised: December 8, 2025
Accepted: January 6, 2026
Published online: March 15, 2026
Processing time: 114 Days and 17.5 Hours
Core Tip
Core Tip: Ablative therapies are transforming the therapeutic landscape of locally advanced pancreatic cancer. Among these, cryoablation stands out for its unique dual mechanism – precise cytoreduction and potent immune activation. Incorporation of ablative modalities into multimodal protocols promises improved local control and novel systemic synergy.