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Microbiota-driven immunometabolic regulation in colorectal cancer: Mechanisms and therapeutic opportunities
Wen-Yu Luan, Shu-Ping Zhang, Kai-Zhen Xu, Yu-Hui Shang, Wen-Jian Hu, Hui Sun, Yan-Dong Miao
Wen-Yu Luan, Shu-Ping Zhang, Kai-Zhen Xu, Yu-Hui Shang, Wen-Jian Hu, Yan-Dong Miao, Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, Yantai 264100, Shandong Province, China
Wen-Yu Luan, Yu-Hui Shang, Hui Sun, Yan-Dong Miao, Research and Translational Center for Immunological Disorders, Binzhou Medical University, Yantai 264100, Shandong Province, China
Kai-Zhen Xu, Department of Comprehensive Oncology V, Shandong Provincial Public Health Clinical Centre, Jinan 250000, Shandong Province, China
Yan-Dong Miao, Guangdong Provincial Key Laboratory of Medical Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510000, Guangdong Province, China
Yan-Dong Miao, Department of Oncology, Xinhui District People's Hospital, Jiangmen 529100, Guangdong Province, China
Co-first authors: Wen-Yu Luan and Shu-Ping Zhang.
Co-corresponding authors: Hui Sun and Yan-Dong Miao.
Author contributions: Luan WY and Zhang SP contribute equally to this study as co-first authors; Luan WY performed the literature retrieval, wrote the manuscript, and images drawing; Zhang SP, Xu KZ, Shang YH, and Hu WJ performed the data analysis; Sun H and Miao YD were designated as co-corresponding authors. Sun H was responsible for the evolution of overarching research goals and aims, specifically critical review, management and coordination responsibility for the research activity planning and execution, acquisition of the financial support for the project leading to this publication, while Miao YD was responsible for review and editing the draft, oversight, and leadership responsibility for the research activity planning and execution, including mentorship external to the core team; all authors approved the final manuscript.
Supported by Shandong Province Medical and Health Science and Technology Development Plan Project, No. 202203030713; Yantai Science and Technology Program, No. 2024YD005, No. 2024YD007, and No. 2024YD010; and Science and Technology Program of Yantai Affiliated Hospital of Binzhou Medical University, No. YTFY2022KYQD06.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Corresponding author: Yan-Dong Miao, MD, Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2
nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai 264100, Shandong Province, China.
miaoyd_22@bzmc.edu.cn
Received: October 24, 2025
Revised: December 9, 2025
Accepted: December 30, 2025
Published online: March 15, 2026
Processing time: 140 Days and 9.7 Hours
