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World J Gastrointest Oncol. Mar 15, 2026; 18(3): 113781
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.113781
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.113781
MiR-27b-5p promotes gastric cancer progression by targeting CREBZF to regulate the STAT3 pathway
Fu-Chao Ma, Wei Peng, Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Guan-Lan Zhang, Guo-Qiang Chen, Jing-Wen Ling, Yu-Feng Li, Bang-Teng Chi, Yu-Lu Tang, Gang Chen, Dan-Ming Wei, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Jing-Wen Ling, Department of Medical Information Engineering, School of Information and Management, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Min-Hua Rong, Department of Research, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Lian-Ying Ge, Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Co-first authors: Fu-Chao Ma and Guan-Lan Zhang.
Co-corresponding authors: Min-Hua Rong and Lian-Ying Ge.
Author contributions: Ma FC and Zhang GL contributed equally as co-first authors; Ma FC, Zhang GL, Chen G, and Wei DM designed the research; Ma FC and Zhang GL collected clinical information and conducted the small RNA-sequencing and real-time quantitative reverse transcription polymerase chain reaction experiments; Ma FC, Zhang GL, Chen GQ, and Ling JW screened and processed the public small RNA sequencing datasets; Chen GQ, Ling JW, Peng W, and Tang YL analyzed the data; Ma FC, Zhang GL, Chi BT, Tang YL, and Peng W wrote the draft; Rong MH and Ge LY participated in manuscript revision and contributed equally as co-corresponding authors; all authors read and approved the final manuscript.
Supported by Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project, No. Z-A20220465; Guangxi Key Research and Development Plan, No. AB20297021; Guangxi Medical and Health Appropriate Technology Development and Promotion Application Project, No. S2022107; China Undergraduate Innovation and Entrepreneurship Training Program, No. S202310598074; and Future Academic Star of Guangxi Medical University, No. WLXSZX23109.
Institutional review board statement: This study was reviewed and approved by the Ethics Committees of Guangxi Medical University Cancer Hospital, No. KY2020148; Guilin People’s Hospital, No. 2020-102KY; and Youjiang Medical University, No. YYFY-LL-2024-005.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Ethics Committee of the Guangxi Medical University Animal Center, No. KY2020149.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data used to support the findings of this study are available from the corresponding author upon request.
Corresponding author: Lian-Ying Ge, Department of Endoscopy, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. gxgly@hotmail.com
Received: September 3, 2025
Revised: November 1, 2025
Accepted: December 23, 2025
Published online: March 15, 2026
Processing time: 190 Days and 21.6 Hours
Revised: November 1, 2025
Accepted: December 23, 2025
Published online: March 15, 2026
Processing time: 190 Days and 21.6 Hours
Core Tip
Core Tip: Our findings provide preliminary evidence that reduction of miR-27b-5p restrains proliferation and migration of gastric cancer cells. Our investigation also indicates that elevated expression level of miR-27b-5p suppresses gene exp