Arun O, Arun F. Does anesthesia choice shape oncologic destiny in gastric cancer surgery? World J Gastrointest Oncol 2026; 18(2): 115944 [DOI: 10.4251/wjgo.v18.i2.115944]
Corresponding Author of This Article
Oguzhan Arun, MD, PhD, Professor, Department of Anesthesiology and Reanimation, Selcuk University Faculty of Medicine, Alaaddin Keykubat Kampus, Konya 42130, Türkiye. oguzarun@selcuk.edu.tr
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Anesthesiology
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Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 15, 2026 (publication date) through Feb 3, 2026
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Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Arun O, Arun F. Does anesthesia choice shape oncologic destiny in gastric cancer surgery? World J Gastrointest Oncol 2026; 18(2): 115944 [DOI: 10.4251/wjgo.v18.i2.115944]
World J Gastrointest Oncol. Feb 15, 2026; 18(2): 115944 Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.115944
Does anesthesia choice shape oncologic destiny in gastric cancer surgery?
Oguzhan Arun, Funda Arun
Oguzhan Arun, Department of Anesthesiology and Reanimation, Selcuk University Faculty of Medicine, Konya 42130, Türkiye
Funda Arun, Division of Anesthesiology, Department of Pedodontics, Selcuk University Faculty of Dentistry, Konya 42130, Türkiye
Author contributions: Arun O and Arun F contributed substantially to the conception and design of the study, acquisition, analysis and interpretation of data, and drafting or critical revision of the manuscript for important intellectual content. All authors approved the final version of the manuscript and agree to be accountable for all aspects of the work.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest, financial or otherwise, related to the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Oguzhan Arun, MD, PhD, Professor, Department of Anesthesiology and Reanimation, Selcuk University Faculty of Medicine, Alaaddin Keykubat Kampus, Konya 42130, Türkiye. oguzarun@selcuk.edu.tr
Received: October 29, 2025 Revised: November 17, 2025 Accepted: December 10, 2025 Published online: February 15, 2026 Processing time: 97 Days and 2.8 Hours
Core Tip
Core Tip: Anesthetic choice in gastric cancer surgery extends beyond technical preference, potentially influencing immune function, stress response, and oncologic outcomes. Propofol-based total intravenous anesthesia demonstrates promising molecular and clinical anti-tumor properties-modulating microRNAs, enhancing natural killer cell activity, and improving post-operative recovery-while sevoflurane, though traditionally considered neutral, shows emerging immunoregulatory and gene-expression effects. Current evidence, including the recent Wang et al’s study, suggests both agents yield comparable perioperative safety and survival outcomes; however, their distinct molecular profiles highlight anesthesia as a modifiable element in personalized cancer care. Future biomarker-driven research is essential to clarify when and how anesthetic selection might influence long-term oncologic prognosis.
