Huang L, Li JT, Zhou WJ, Wu QF. Endoscopic vs laparoscopic resection for gastric gastrointestinal stromal tumors: Oncological outcomes. World J Gastrointest Oncol 2026; 18(2): 115199 [DOI: 10.4251/wjgo.v18.i2.115199]
Corresponding Author of This Article
Qin-Fang Wu, Attending Physician, Department of Gastroenterology, JiuJiang No. 1 People’s Hospital, Jiujiang City Key Laboratory of Cell Therapy, No. 48 Taling South Road, Jiujiang 332000, Jiangxi Province, China. 15870842289@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Feb 15, 2026; 18(2): 115199 Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.115199
Endoscopic vs laparoscopic resection for gastric gastrointestinal stromal tumors: Oncological outcomes
Lan Huang, Jiang-Tao Li, Wen-Jie Zhou, Qin-Fang Wu
Lan Huang, Jiang-Tao Li, Wen-Jie Zhou, Qin-Fang Wu, Department of Gastroenterology, JiuJiang No. 1 People’s Hospital, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang 332000, Jiangxi Province, China
Author contributions: Huang L conceived and designed the study, collected and analyzed clinical data, drafted the manuscript; Wu QF supervised the entire study design and data analysis, revised the manuscript critically for important intellectual content, and finalized the submission; Li JT and Zhou WJ assisted in data collection, participated in follow-up of patients, and checked data accuracy; all authors have read and approved the final manuscript.
Supported by Jiujiang Basic Research Program Project, No. S2024KXJJ0001.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of JiuJiang No. 1 People’s Hospital (Approval No. JJSDYRMYY-YXLL-2023-2389).
Informed consent statement: All study participants and their legal guardians provided written informed consent before recruitment into the study.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qin-Fang Wu, Attending Physician, Department of Gastroenterology, JiuJiang No. 1 People’s Hospital, Jiujiang City Key Laboratory of Cell Therapy, No. 48 Taling South Road, Jiujiang 332000, Jiangxi Province, China. 15870842289@163.com
Received: October 17, 2025 Revised: November 22, 2025 Accepted: December 11, 2025 Published online: February 15, 2026 Processing time: 108 Days and 17.6 Hours
Core Tip
Core Tip: This study compared the efficacy of endoscopic and laparoscopic resection for localized gastric gastrointestinal stromal tumors (LGISTs) using propensity score matching to control for baseline bias. Endoscopic resection was found to be superior in terms of reduced operation time, blood loss, and postoperative hospital stay, while achieving comparable mid-term oncological outcomes (3-year recurrence-free survival and overall survival) to laparoscopic resection. Tumor size, mitotic count, and National Institutes of Health risk stratification were key factors affecting prognosis, and the surgical approach had no direct influence on recurrence risk. The study provides evidence-based support for “prioritizing minimally invasive endoscopic treatment for carefully selected LGIST patients”.
