©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2026; 18(2): 113995
Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.113995
Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.113995
Recent advances in spasmolytic polypeptide expressing metaplasia research
Rui-Rui Yang, First Clinical School, Liaoning University of Chinese Medicine, Shenyang 110847, Liaoning Province, China
Rui-Rui Yang, Yu-Feng Li, Department of Gastroenterology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China
Ya-Ru Yan, Heilongjiang Provincial Academy of Traditional Chinese Medicine, Harbin 150036, Heilongjiang Province, China
Co-first authors: Rui-Rui Yang and Ya-Ru Yan.
Author contributions: Yang RR and Yan YR contributed equally to this study as co-first authors. Yang RR and Yan YR contributed to the conceptualization of the study, interpretation of the data, and wrote the manuscript; Li YF revised the manuscript.
Supported by Liaoning Provincial Science and Technology Plan Joint Plan (Applied Basic Research Program), No. 2023JH2/101700226; and Liaoning Provincial Traditional Chinese Medicine Interdisciplinary Innovation Team Project, No. LNZYYCXTD-JCCX-002.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Yu-Feng Li, Chief Physician, Professor, Department of Gastro
Received: September 9, 2025
Revised: October 23, 2025
Accepted: December 10, 2025
Published online: February 15, 2026
Processing time: 147 Days and 18.4 Hours
Revised: October 23, 2025
Accepted: December 10, 2025
Published online: February 15, 2026
Processing time: 147 Days and 18.4 Hours
Core Tip
Core Tip: Gastric cancer is one of the most common cancers worldwide, with exceptionally high morbidity and fatality rates. A thorough investigation of the pathophysiology of spasmolytic polypeptide-expressing metaplasia (SPEM) is required. SPEM serves as a critical nexus between mucosal repair and gastric carcinogenesis and is a valuable target for early detection and intervention. To gain a deeper understanding of SPEM, this review summarizes its recent mechanistic roles in gastric mucosal diseases. By elucidating these mechanisms, this review aims to provide deeper insights into the research and prevention of SPEM-related diseases.