Yang RR, Yan YR, Li YF. Recent advances in spasmolytic polypeptide expressing metaplasia research. World J Gastrointest Oncol 2026; 18(2): 113995 [DOI: 10.4251/wjgo.v18.i2.113995]
Corresponding Author of This Article
Yu-Feng Li, Chief Physician, Professor, Department of Gastroenterology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huanggu District, Shenyang 110847, Liaoning Province, China. 3278086072@qq.com
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Gastroenterology & Hepatology
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Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 15, 2026 (publication date) through Feb 3, 2026
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Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Yang RR, Yan YR, Li YF. Recent advances in spasmolytic polypeptide expressing metaplasia research. World J Gastrointest Oncol 2026; 18(2): 113995 [DOI: 10.4251/wjgo.v18.i2.113995]
World J Gastrointest Oncol. Feb 15, 2026; 18(2): 113995 Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.113995
Recent advances in spasmolytic polypeptide expressing metaplasia research
Rui-Rui Yang, Ya-Ru Yan, Yu-Feng Li
Rui-Rui Yang, First Clinical School, Liaoning University of Chinese Medicine, Shenyang 110847, Liaoning Province, China
Rui-Rui Yang, Yu-Feng Li, Department of Gastroenterology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China
Ya-Ru Yan, Heilongjiang Provincial Academy of Traditional Chinese Medicine, Harbin 150036, Heilongjiang Province, China
Co-first authors: Rui-Rui Yang and Ya-Ru Yan.
Author contributions: Yang RR and Yan YR contributed equally to this study as co-first authors. Yang RR and Yan YR contributed to the conceptualization of the study, interpretation of the data, and wrote the manuscript; Li YF revised the manuscript.
Supported by Liaoning Provincial Science and Technology Plan Joint Plan (Applied Basic Research Program), No. 2023JH2/101700226; and Liaoning Provincial Traditional Chinese Medicine Interdisciplinary Innovation Team Project, No. LNZYYCXTD-JCCX-002.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Feng Li, Chief Physician, Professor, Department of Gastroenterology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huanggu District, Shenyang 110847, Liaoning Province, China. 3278086072@qq.com
Received: September 9, 2025 Revised: October 23, 2025 Accepted: December 10, 2025 Published online: February 15, 2026 Processing time: 147 Days and 14 Hours
Abstract
Gastric cancer remains a leading cause of global cancer mortality, with limited advances in its prevention and treatment owing to an incomplete understanding of its pathogenesis. Among the key precancerous lesions, spasmolytic polypeptide-expressing metaplasia has emerged as a critical driver in gastric carcinogenesis. This review summarizes the recent advances in the mechanistic roles of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases. By elucidating these pathways, this review sought to provide novel insights that could inform future strategies for early intervention and prevention of gastric cancer.
Core Tip: Gastric cancer is one of the most common cancers worldwide, with exceptionally high morbidity and fatality rates. A thorough investigation of the pathophysiology of spasmolytic polypeptide-expressing metaplasia (SPEM) is required. SPEM serves as a critical nexus between mucosal repair and gastric carcinogenesis and is a valuable target for early detection and intervention. To gain a deeper understanding of SPEM, this review summarizes its recent mechanistic roles in gastric mucosal diseases. By elucidating these mechanisms, this review aims to provide deeper insights into the research and prevention of SPEM-related diseases.
