Helicobacter pylori-related non-coding RNAs in gastric cancer screening: Emerging evidence and translational challenges

doi:10.4251/wjgo.v18.i1.114312

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Jan 15, 2026 (publication date) through Jan 12, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jan 15, 2026; 18(1): 114312
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.114312

Helicobacter pylori-related non-coding RNAs in gastric cancer screening: Emerging evidence and translational challenges

Zuo-Po Lv, Muhammad Haris Sultan, Yi-Gang Wang

Zuo-Po Lv, Muhammad Haris Sultan, Yi-Gang Wang, Department of Biotechnology, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China

Author contributions: Lv ZP, Sultan MH, and Wang YG contributed to this paper; Lv ZP and Wang YG designed the outline of the manuscript; Lv ZP, Sultan MH, and Wang YG contributed to the writing and editing of the manuscript and review of the literature.

Supported by The Joint Fund of Zhejiang Provincial Natural Science Foundation of China, No. LKLY25H160002.

Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Yi-Gang Wang, PhD, Professor, Department of Biotechnology, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 2 Street of Xiasha District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com

Received: September 16, 2025
Revised: September 30, 2025
Accepted: October 27, 2025
Published online: January 15, 2026
Processing time: 118 Days and 18.2 Hours

Core Tip

Core Tip: Helicobacter pylori (H. pylori) infection is the main risk factor for gastric cancer (GC). However, early diagnosis of GC remains challenging due to the lack of obvious symptoms. In GC, some non-coding RNAs (ncRNAs) dysregulated following H. pylori infection show potential as early diagnostic biomarkers. Understanding the role of ncRNAs in H. pylori-associated GC may improve early detection and patient prognosis.