Lv ZP, Sultan MH, Wang YG. Helicobacter pylori-related non-coding RNAs in gastric cancer screening: Emerging evidence and translational challenges. World J Gastrointest Oncol 2026; 18(1): 114312 [PMID: 41607748 DOI: 10.4251/wjgo.v18.i1.114312]
Corresponding Author of This Article
Yi-Gang Wang, PhD, Professor, Department of Biotechnology, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 2 Street of Xiasha District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com
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Cell Biology
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Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 15, 2026 (publication date) through Feb 4, 2026
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World Journal of Gastrointestinal Oncology
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1948-5204
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Lv ZP, Sultan MH, Wang YG. Helicobacter pylori-related non-coding RNAs in gastric cancer screening: Emerging evidence and translational challenges. World J Gastrointest Oncol 2026; 18(1): 114312 [PMID: 41607748 DOI: 10.4251/wjgo.v18.i1.114312]
World J Gastrointest Oncol. Jan 15, 2026; 18(1): 114312 Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.114312
Helicobacter pylori-related non-coding RNAs in gastric cancer screening: Emerging evidence and translational challenges
Zuo-Po Lv, Muhammad Haris Sultan, Yi-Gang Wang
Zuo-Po Lv, Muhammad Haris Sultan, Yi-Gang Wang, Department of Biotechnology, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China
Author contributions: Lv ZP, Sultan MH, and Wang YG contributed to this paper; Lv ZP and Wang YG designed the outline of the manuscript; Lv ZP, Sultan MH, and Wang YG contributed to the writing and editing of the manuscript and review of the literature.
Supported by The Joint Fund of Zhejiang Provincial Natural Science Foundation of China, No. LKLY25H160002.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Gang Wang, PhD, Professor, Department of Biotechnology, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 2 Street of Xiasha District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com
Received: September 16, 2025 Revised: September 30, 2025 Accepted: October 27, 2025 Published online: January 15, 2026 Processing time: 118 Days and 18.2 Hours
Abstract
Gastric cancer (GC) has high morbidity and mortality worldwide. Due to the absence of noticeable symptoms, diagnosing GC at an early stage is very difficult, which consequently leads to advanced GC and poor prognosis. Effective biomarkers are essential for prolonging patients’ survival. Helicobacter pylori (H. pylori) infection represents the most significant risk factor for GC, with nearly all cases linked to this infection. Many non-coding RNAs (ncRNAs) are dysregulated in H. pylori-infected GC, indicating that ncRNAs may serve as biomarkers of early-stage GC. In this editorial, we discuss the study by Chen et al. Although previous studies have identified roles for miR-136 in gastric cancer proliferation, apoptosis, and invasion, none have specifically explored its relationship with H. pylori-associated gastric carcinogenesis.
Core Tip: Helicobacter pylori (H. pylori) infection is the main risk factor for gastric cancer (GC). However, early diagnosis of GC remains challenging due to the lack of obvious symptoms. In GC, some non-coding RNAs (ncRNAs) dysregulated following H. pylori infection show potential as early diagnostic biomarkers. Understanding the role of ncRNAs in H. pylori-associated GC may improve early detection and patient prognosis.
