Tight junction proteins: Gatekeepers turned facilitators in the pathogenesis of gastric adenocarcinoma

doi:10.4251/wjgo.v18.i1.114040

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Jan 15, 2026 (publication date) through Feb 23, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jan 15, 2026; 18(1): 114040
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.114040

Tight junction proteins: Gatekeepers turned facilitators in the pathogenesis of gastric adenocarcinoma

Shobha Selvam, Balasubramaniyan Vairappan

Shobha Selvam, Balasubramaniyan Vairappan, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India

Co-first authors: Shobha Selvam and Balasubramaniyan Vairappan.

Author contributions: Selvam S and Vairappan B contributed equally to this manuscript and are co-first authors. Selvam S and Vairappan B contributed to the manuscript writing and revisions.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Balasubramaniyan Vairappan, PhD, Additional Professor, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India. balasubramaniyan.v@jipmer.edu.in

Received: September 10, 2025
Revised: October 21, 2025
Accepted: November 24, 2025
Published online: January 15, 2026
Processing time: 124 Days and 18 Hours

Core Tip

Core Tip: Tight junction (TJ) proteins play a pivotal role in preserving the integrity of the gastric epithelial barrier. Their dysregulation represents a critical early event linking chronic inflammation to gastric carcinogenesis. Inflammatory mediators induce TJ remodeling, thereby increasing mucosal permeability and promoting tumor initiation and progression. Emerging therapeutic strategies targeting TJ proteins either by pharmacologically restoring barrier integrity or modulating aberrant TJ signaling offer promising avenues to suppress inflammation, inhibit tumor growth and metastasis, and ultimately improve clinical outcomes in gastric cancer patients.