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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2026; 18(1): 110102
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.110102
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.110102
Discrepancies between preoperative assessment and final pathological criteria in early gastric cancer
Mo-Yi-Ge Jize, Wei Wu, Shi-Gang Ding, Jing Zhang, Department of Gastroenterology, Peking University Third Hospital, Beijing 100083, China
Mo-Yi-Ge Jize, Wei Wu, Shi-Gang Ding, Jing Zhang, Department of Gastroenterology, Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases (BZ0371), Beijing 100083, China
Author contributions: Jize MYG, Ding SG, and Zhang J designed the study; Jize MYG and Wu W were responsible for developing the methodology and participated in formal analysis and investigation; Jize MYG wrote the original draft; Ding SG and Zhang J participated in manuscript review and editing.
Supported by China Health & Medical Development Foundation, No. M2021551.
Institutional review board statement: This study was reviewed and approved by the Peking University Third Hospital Medical Science Research Ethics Committee (Approval No. 2021-509-02).
Informed consent statement: The need for informed consent was waived by the Peking University Third Hospital Medical Science Research Ethics Committee (Approval No. 2021-509-02).
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Zhang, MD, Associate Professor, Chief Physician, Department of Gastroenterology, Peking University Third Hospital, No. 49 Huayuan North Road, Haidian District, Beijing 100083, China. sihuizhang@sina.com
Received: May 30, 2025
Revised: July 5, 2025
Accepted: November 13, 2025
Published online: January 15, 2026
Processing time: 227 Days and 19.1 Hours
Revised: July 5, 2025
Accepted: November 13, 2025
Published online: January 15, 2026
Processing time: 227 Days and 19.1 Hours
Core Tip
Core Tip: Current Japanese guideline-based therapeutic indications for early gastric cancer show 74.4% concordance with postoperative pathological criteria in this cohort of 796 patiensts (2010-2022). Key discordance risk factors are tumors in the upper third stomach (prone to pathological underestimation) and undifferentiated histology (prone to overestimation). These findings necessitate heightened preoperative vigilance: endoscopic reevaluation with mapping biopsies for proximal lesions to address technical challenges and avoid non-curative and secondary resections.