Hao QL, Yao ZY, Shen YM, Li ZY, Gao HC, Hong XY, Li GC, Gao C. Prognostic significance of preoperative C-reactive protein-triglyceride-glucose index in long-term outcomes after radical gastrectomy for gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113976 [DOI: 10.4251/wjgo.v17.i12.113976]
Corresponding Author of This Article
Chao Gao, MD, Professor, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221000, Jiangsu Province, China. gaochaoly@sina.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 15, 2025 (publication date) through Dec 17, 2025
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Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Hao QL, Yao ZY, Shen YM, Li ZY, Gao HC, Hong XY, Li GC, Gao C. Prognostic significance of preoperative C-reactive protein-triglyceride-glucose index in long-term outcomes after radical gastrectomy for gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113976 [DOI: 10.4251/wjgo.v17.i12.113976]
World J Gastrointest Oncol. Dec 15, 2025; 17(12): 113976 Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113976
Prognostic significance of preoperative C-reactive protein-triglyceride-glucose index in long-term outcomes after radical gastrectomy for gastric cancer
Qiu-Lin Hao, Zhi-Yuan Yao, Yu-Meng Shen, Zheng-Yu Li, Hao-Chun Gao, Xiao-Yu Hong, Geng-Chen Li, Chao Gao, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
Co-first authors: Qiu-Lin Hao and Zhi-Yuan Yao.
Author contributions: Gao C, Hao QL, and Yao ZY designed the research; Gao HC, Hong XY, and Li GC have made contributions to data collection and organization; Shen YM and Li ZY conducted statistical analysis; Hao QL and Yao ZY made equal contributions to writing the original draft, and they are co first authors; all authors have read and approved the final manuscript.
Institutional review board statement: This research was carried out following the Declaration of Helsinki and received approval from the Ethics Committee at the Affiliated Hospital of Xuzhou Medical University (No. XYFY2023-KL277-01).
Informed consent statement: Given the retrospective design of this investigation, the Ethics Committee of the Affiliated Hospital of Xuzhou Medical University granted us an exemption from obtaining written informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The data included in this study can be obtained from the corresponding author at gaochaoly@sina.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao Gao, MD, Professor, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221000, Jiangsu Province, China. gaochaoly@sina.com
Received: September 9, 2025 Revised: September 26, 2025 Accepted: November 6, 2025 Published online: December 15, 2025 Processing time: 94 Days and 5.4 Hours
Core Tip
Core Tip: Gastric cancer is the third leading cause of cancer-related mortality worldwide. Radical surgery remains the primary treatment for early-stage gastric cancer, but the overall survival rate post-surgery remains relatively low. Identifying key prognostic factors is essential to optimize treatment strategies. The C-reactive protein-triglyceride-glucose (CTI) index, which integrates both inflammatory and metabolic markers, has garnered increasing attention in cancer research, particularly in gastric cancer prognosis. However, few studies have explored the impact of CTI on cancer patient outcomes. Therefore, we conducted a retrospective clinical study to examine the influence of CTI on the prognosis of patients undergoing radical gastrectomy for gastric cancer and developed a corresponding predictive model. Additionally, we incorporated the prognostic nutritional index coefficient to improve the predictive accuracy of the model.
