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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2025; 17(12): 113661
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113661
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113661
Clinical characteristics and prognostic analysis of three hundred and nineteen cases of primary gastrointestinal diffuse large B-cell lymphoma
Jia-Jia Ma, Huan Zhang, Cui-Cui Wang, Wen-Li Ji, Xin-Xia Li, Pathology Center, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Ying Zhao, Department of General Practice, The Third People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Author contributions: Ma JJ contributed to conception and design of the research, applied funding, and drafted the manuscript; Zhang H conducted experiments; Wang CC performed statistical analysis; Li XX, Ji WL, and Li XX revised the manuscript for important intellectu
Supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region, No. 2022D01D21; “Tianshan Talents” Cultivation Program of Xinjiang Uygur Autonomous Region, No. 2024TSYCLJ0025; and National Natural Science Foundation of China, No. 82360037.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Xinjiang Medical University Affiliat
Informed consent statement: Informed consent was waived due to the study's retrospective nature, and all patient data were anonymiz
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated and/or analyzed during the current study are not publicly available due to patient priva
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Xia Li, PhD, Chief Physician, Professor, Pathology Center, Xinjiang Medical University Affiliated Tumor Hospital, No. 789 Suzhou East Street, Xinshi District, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. lxxpatho@163.com
Received: September 1, 2025
Revised: September 18, 2025
Accepted: November 5, 2025
Published online: December 15, 2025
Processing time: 102 Days and 17 Hours
Revised: September 18, 2025
Accepted: November 5, 2025
Published online: December 15, 2025
Processing time: 102 Days and 17 Hours
Core Tip
Core Tip: Primary gastrointestinal diffuse large B-cell lymphoma predominantly affects elderly men over 60 years, with abdominal pain, distension, and significant weight loss as common initial symptoms. Lesions are primarily located in the gastric body, antrum, and colon, often presenting as ulcerative or raised masses on endoscopy. Key independent prognostic risk factors include age > 60 years, presence of B symptoms, and elevated serum lactate dehydrogenase > 250 U/L, which correlate with poor survival outcomes and necessitate early diagnosis and targeted therapy.