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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2025; 17(12): 112761
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.112761
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.112761
Clinical characteristics of colorectal polyps in patients with non-alcoholic fatty liver disease in high altitude areas
Chun-Yan Wang, Department of Gastroenterology, Tianjin Second People’s Hospital, Tianjin Institute of Hepatology, Clinical School of the Second People’s Hospital, Tianjin Medical University, Tianjin 300110, China
Lin Ma, Ying Zhao, Xiao-Jiang Zhang, Graduate School, Tianjin Medical University, Tianjin 300070, China
Shuang Li, Endoscopy Center, Tianjin Second People’s Hospital, Tianjin 300110, China
Yong-Gang Liu, Department of Pathology, Tianjin Second People’s Hospital, Tianjin 300110, China
Hai-Ming Guo, Jun-Guo Qi, Jian-Quan Wang, Wei-Xin Ye, Jian-Zhou Li, Tao Zhang, Diagnosis and Treatment Center of High Altitude Digestive Disease, Xining Second People’s Hospital, Xining 810003, Qinghai Province, China
Co-first authors: Chun-Yan Wang and Lin Ma.
Co-corresponding authors: Jian-Zhou Li and Tao Zhang.
Author contributions: Wang CY and Ma L wrote the manuscript; Zhang XJ, Li S, Guo HM and Qi JG contributed to data collation; Zhao Y and Ma L contributed to statistical analysis; Liu YG contributed to liver pathology reading; Wang CY, Wang JQ and Ye WX contributed to manuscript revision; Wang CY, Li JZ and Zhang T contributed to research supervision; Wang CY contributed to project design. All authors have read and approve the final manuscript. Wang CY and Ma L contributed equally to this work as co-first authors. Li JZ, as the primary academic supervisor and the originator of the core research concept, was instrumental in the study's design, intellectual direction, and data interpretation. They will be the primary point of contact for inquiries related to the methodological framework and scientific hypotheses. Concurrently, Zhang T, as the principal investigator providing the essential clinical platform and financial support, oversaw the project's execution, ensured resource availability, and contributed significantly to the final critical revision of the manuscript. They will primarily address questions concerning the overall project governance, clinical implications, and resource management. We believe that this dual corresponding authorship structure ensures that all scholarly inquiries, from specific methodological details to broader project-related questions, can be addressed most comprehensively and efficiently during the peer-review process.
Supported by Tianjin Key Medical Discipline Construction Project, No. TJYXZDXK-3-019B.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the Tianjin Second People’s Hospital.
Informed consent statement: Patients were not required to provide informed consent for the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment via written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tao Zhang, Diagnosis and Treatment Center of High Altitude Digestive Disease, Xining Second People’s Hospital, No. 892 Qilian Road, Chengbei District, Xining 810003, Qinghai Province, China. zhangtaoqh@163.com
Received: August 5, 2025
Revised: September 14, 2025
Accepted: November 10, 2025
Published online: December 15, 2025
Processing time: 128 Days and 6.7 Hours
Revised: September 14, 2025
Accepted: November 10, 2025
Published online: December 15, 2025
Processing time: 128 Days and 6.7 Hours
Core Tip
Core Tip: This retrospective study explored the incidence and characteristics of colorectal polyps in patients with non-alcoholic fatty liver disease (NAFLD) from high-altitude (Qinghai) and low-altitude (Tianjin) regions in China. Patient data were analyzed using SPSS 26.0. It was found that NAFLD patients from high-altitude regions had a higher incidence of colorectal polyps, of which the proportion of adenomatous polyps was significantly higher. Sex, smoking, hypertension, and white blood cell counts were observed to be risk factors for the development of adenomatous polyps. Proactive colonoscopy screening is recommended for NAFLD patients with these risk factors living at high altitudes to mitigate the risk of colorectal cancer.