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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2025; 17(10): 110523
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.110523
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.110523
Microenvironmental code of pancreatic ductal adenocarcinoma: The prognostic symphony of budding, matrix and lymphocytes
Qing-Qing Zhou, Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China
Yi-Meng Ren, Endoscopy Center and Endoscopy Research Institute, Shanghai Collaborative Innovation Center of Endoscopy, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Su-Ming Shi, ENT Institute, Department of Otorhinolaryngology, Eye & ENT Hospital, NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China
Teng-Fei Liu, Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
Co-first authors: Qing-Qing Zhou and Yi-Meng Ren.
Co-corresponding authors: Su-Ming Shi and Teng-Fei Liu.
Author contributions: Zhou QQ and Ren YM contributed to the conception and design of the study, acquisition of data, analysis and interpretation of data, and drafting the article, they contributed equally to this manuscript and are co-first authors; Shi SM and Liu TF equally contributed to conceiving and drafting the initial article, and Shi SM and Liu TF were responsible for the critical revision and final approval of the manuscript and are co-corresponding authors.
Supported by National Natural Science Foundation of China, No. 82404058; Shanghai Municipal Commission of Health and Family Planning, No. 2024ZZ2049; and Beijing Xisike Clinical Oncology Research Foundation, No. Y-HS202401-0011.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Teng-Fei Liu, PhD, Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No. 241 Huaihai West Road, Shanghai 200030, China. liutfei@alumni.sjtu.edu.cn
Received: June 12, 2025
Revised: July 18, 2025
Accepted: August 18, 2025
Published online: October 15, 2025
Processing time: 128 Days and 5.1 Hours
Revised: July 18, 2025
Accepted: August 18, 2025
Published online: October 15, 2025
Processing time: 128 Days and 5.1 Hours
Core Tip
Core Tip: This editorial discusses recent research article published by Alpsoy et al, focusing on the synergistic prognostic value of tumor budding, fibroblast response, and tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma. The article reviewed herein cover topics, and provide some insights for application of tumor microenvironment markers in clinical practices.