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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2025; 17(10): 109503
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.109503
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.109503
Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions
Xin-Xin Liu, Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Bing Yang, Youth Leaque Committee, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550001, Guizhou Province, China
Dong-Xin Tang, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, Guizhou Province, China
Author contributions: Liu XX conceptualization, literature review and original draft; Yang B writing, review and editing; Tang DX supervision, conceptualization, review and editing.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Xin Tang, MD, Chief Physician, Professor, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, No. 4 Dongqing Road, Huaxi District, Guiyang 550025, Guizhou Province, China. tdx7712@163.com
Received: June 5, 2025
Revised: July 18, 2025
Accepted: September 16, 2025
Published online: October 15, 2025
Processing time: 131 Days and 0 Hours
Revised: July 18, 2025
Accepted: September 16, 2025
Published online: October 15, 2025
Processing time: 131 Days and 0 Hours
Core Tip
Core Tip: This review explores the bidirectional regulation of the microbiota-immune axis in the immune microenvironment of colorectal cancer (CRC). It discusses how gut microbiota influences immune responses and how the immune system modulates microbiota composition. Highlighting the complexity of these interactions, the review addresses unanswered questions about microbiota heterogeneity and its impact on therapeutic outcomes. It also examines targeted interventions and their potential to improve CRC treatment, offering new insights into both the basic mechanisms and clinical applications for effective therapy.