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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2020; 12(6): 677-686
Published online Jun 15, 2020. doi: 10.4251/wjgo.v12.i6.677
Published online Jun 15, 2020. doi: 10.4251/wjgo.v12.i6.677
Clinical significance of expression of fibrous sheath interacting protein 1 in colon cancer
Hui-Ying Wu, Bin Yang, Department of Nursing, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Dong-Hua Geng, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Wu HY, Yang B, and Geng DH contributed to the writing and revising of the manuscript.
Institutional review board statement: The study was approved by the Ethics committee of Shengjing Hospital of China Medical University.
Informed consent statement: Informed written consent was obtained from the patients.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The manuscript was revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dong-Hua Geng, MD, PhD, Associate Professor, Department of General Surgery, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. gdh024@163.com
Received: February 24, 2020
Peer-review started: February 24, 2020
First decision: March 24, 2020
Revised: April 11, 2020
Accepted: May 5, 2020
Article in press: May 5, 2020
Published online: June 15, 2020
Processing time: 112 Days and 2.2 Hours
Peer-review started: February 24, 2020
First decision: March 24, 2020
Revised: April 11, 2020
Accepted: May 5, 2020
Article in press: May 5, 2020
Published online: June 15, 2020
Processing time: 112 Days and 2.2 Hours
Core Tip
Core tip: This study examined the expression of fibrous sheath interacting protein 1 (FSIP1) in 302 patients with colon carcinoma and analysed the follow-up data. The results showed that FSIP1 expression was not correlated with sex, age, tumour size, or other factors but was positively correlated with tumour pathological T/N stages and negatively correlated with tumour differentiation. Univariate and multivariate Cox regression analyses and survival analysis showed that high expression of FSIP1 was an independent risk factor for poor prognosis, and overall survival was worse in the FSIP1-high expression group than in the FSIP1-low expression group. So we speculate that FSIP1 plays a role in the carcinogenesis of colon cancer.