Published online Jun 15, 2020. doi: 10.4251/wjgo.v12.i6.677
Peer-review started: February 24, 2020
First decision: March 24, 2020
Revised: April 11, 2020
Accepted: May 5, 2020
Article in press: May 5, 2020
Published online: June 15, 2020
Processing time: 112 Days and 2.2 Hours
The occurrence and development of colon cancer are complex, involving a variety of genetic changes. Fibrous sheath interacting protein 1 (FSIP1) is a newly discovered oncogene that is frequently activated in a variety of tumours. However, the clinical significance of FSIP1 in colon cancer is unclear. In this study, the authors analysed the clinical significance of expression FSIP1 in human colon cancer, with an aim to clarify the biological role of FSIP1 in the development and progression of colon cancer.
Over the years, many scholars have been constantly looking for markers related to the diagnosis and prognosis of colon cancer. However, only EGFR/K-ras/BRAF and related targeted therapies are commonly accepted. Therefore, markers of broad significance to guide clinical diagnosis and treatment are still urgent needed.
In the study, the authors aimed to clarify the biological function of FSIP1 in the development and progression of colon cancer and its relationship with the clinical parameters.
A total of 302 specimens of tumour tissues and paracancerous tissues from patients with a pathological diagnosis of colon cancer were analyzed. FSIP1 expression in colon cancer tissues and adjacent normal tissues was detected by immunohistochemistry. Spearman correlation coefficient and Cox regression analyses were used to determine the relationship between FSIP1 expression and clinicopathological factors and prognosis, as well as the impact on survival.
Compared with the expression in benign adjacent tissues, the expression of FSIP1 was significantly increased in colon cancer tissues, and the high expression of FSIP1 was positively correlated with colon cancer stage and lymph node metastasis and negatively correlated with tumour differentiation. Spearman correlation analysis was used to determine the correlation between the expression of FSIP1 and various clinicopathological factors. The FSIP1 expression was not correlated with sex, age, tumour size, or other factors but was positively correlated with tumour pathological T stage and lymph node metastasis (N stage) and negatively correlated with tumour differentiation.
High expression of FSIP1 may be one of the important factors affecting the clinical outcome of colon cancer patients and leading to poor prognosis.
From the results, the authors speculate that FSIP1 may become an important molecular marker for the diagnosis, prognosis, and treatment of colon cancer. Although this study only performed preliminary histological validation in human samples, we look forward to further in vitro cell experiments exploring the effects of FSIP1 on many factors of colon cancer cells.