Wang M, Kong WJ, Zhang JZ, Lu JJ, Hui WJ, Liu WD, Kang XJ, Gao F. Association of Helicobacter pylori infection with colorectal polyps and malignancy in China. World J Gastrointest Oncol 2020; 12(5): 582-591 [PMID: 32461789 DOI: 10.4251/wjgo.v12.i5.582]
Corresponding Author of This Article
Feng Gao, MD, PhD, Chairman, Professor, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91, Tianchi Road, Tianshan District, Urumqi 830001, Xinjiang Uygur Autonomous Region, China. drxjgf@sina.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Man Wang, Wen-Jie Kong, Jia-Jie Lu, Wen-Jia Hui, Wei-Dong Liu, Feng Gao, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China
Jing-Zhan Zhang, Xiao-Jing Kang, Department of Dermatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China
Author contributions: Wang M and Gao F designed the study; Wang M, Kong WJ and Lu JJ acquired the data and drafted the article; Hui WJ and Liu WD analyzed and interpreted the data; Zhang JZ and Kang XJ revised the article critically for important intellectual content; all the authors approved the version to be published.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the People’s Hospital of Xinjiang Uygur Autonomous Region.
Informed consent statement: No consent was required as this was a retrospective study.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Data sharing statement: The datasets collected and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Feng Gao, MD, PhD, Chairman, Professor, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91, Tianchi Road, Tianshan District, Urumqi 830001, Xinjiang Uygur Autonomous Region, China. drxjgf@sina.com
Received: December 29, 2019 Peer-review started: December 29, 2019 First decision: January 19, 2020 Revised: March 13, 2020 Accepted: March 24, 2020 Article in press: March 24, 2020 Published online: May 15, 2020 Processing time: 136 Days and 19.3 Hours
Core Tip
Core tip: This study investigated the association of gastric Helicobacter pylori (H. pylori) infection with the risk of colorectal polyps and colorectal cancer (CRC). The results indicated that patients with H. pylori infection were 2.19 and 3.05 times more likely to develop colorectal polyps and CRC, respectively, than those without H. pylori infection. The prevalence of H. pylori infection was higher in the patient group with multiple polyps and colorectal adenomas than in those with a solitary polyp and non-adenomatous polyps, respectively. Gastric H. pylori infection and H. pylori-associated atrophic gastritis or intestinal metaplasia elevated the risk of colorectal polyps and CRC. Therefore, earlier and frequent colonoscopy is necessary.
