Yu H, Rong L, Cai YL, Liu GY, Guo XY. Short- and long-term outcomes after endoscopic resection of sporadic nonampullary duodenal tumors: An 11-year single-center retrospective study. World J Gastrointest Oncol 2026; 18(3): 115737 [DOI: 10.4251/wjgo.v18.i3.115737]
Corresponding Author of This Article
Long Rong, Department of Endoscopy Center, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. long-rongbjpek@hotmail.com
Research Domain of This Article
Oncology
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Retrospective Study
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Mar 15, 2026 (publication date) through Mar 12, 2026
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Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Yu H, Rong L, Cai YL, Liu GY, Guo XY. Short- and long-term outcomes after endoscopic resection of sporadic nonampullary duodenal tumors: An 11-year single-center retrospective study. World J Gastrointest Oncol 2026; 18(3): 115737 [DOI: 10.4251/wjgo.v18.i3.115737]
World J Gastrointest Oncol. Mar 15, 2026; 18(3): 115737 Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.115737
Short- and long-term outcomes after endoscopic resection of sporadic nonampullary duodenal tumors: An 11-year single-center retrospective study
Hang Yu, Long Rong, Yun-Long Cai, Guan-Yi Liu, Xin-Yue Guo
Hang Yu, Long Rong, Yun-Long Cai, Guan-Yi Liu, Xin-Yue Guo, Department of Endoscopy Center, Peking University First Hospital, Beijing 100034, China
Author contributions: Rong L conceiving and designing the study; Cai YL, Liu GY, Guo XY collecting the data; Cai YL, Liu GY, Guo XY analyzing and interpreting the data; Yu H writing the manuscript; Rong L providing critical revisions that are important for the intellectual content; all authors approving the final version of the manuscript.
Supported by National High Level Hospital Clinical Research Funding Interdepartmental Research Project of Peking University First Hospital, No. 2024IR01.
Institutional review board statement: The study complied with the Declaration of Helsinki and was approved by the Institutional Review Board of Peking University First Hospital (No. 2025110).
Informed consent statement: All participants provided written informed consent.
Conflict-of-interest statement: All authors declare that they have no conflict of interests.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at long-rongbjpek@hotmail.com. Participants gave informed consent for data sharing.
Corresponding author: Long Rong, Department of Endoscopy Center, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. long-rongbjpek@hotmail.com
Received: October 31, 2025 Revised: December 17, 2025 Accepted: January 19, 2026 Published online: March 15, 2026 Processing time: 133 Days and 0.4 Hours
Abstract
BACKGROUND
Sporadic nonampullary duodenal tumors (SNADTs) are rare in clinical practice. Endoscopic resection (ER) is widely used in the treatment of SNADTs. However, the clinical outcome following ER for SNADTs remains unclear.
AIM
To evaluate the clinical efficacy of ER for SNADTs.
METHODS
We retrospectively analyzed clinical data and follow-up information for SNADT patients who underwent ER at Peking University First Hospital between January 2013 and May 2024. Patients were grouped by technique: Endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or ESD with snare assistance (ESD-S). The outcomes included procedure time, complications, en bloc resection, complete resection, and recurrence during short- and long-term follow-up.
RESULTS
A total of 124 consecutive patients were included (EMR 66; ESD 26; ESD-S 32). Procedure time differed significantly among the three groups. The en bloc resection rates were 87.9% (EMR), 100% (ESD), and 93.8% (ESD-S). The complete resection rates were 87.9% (EMR), 80.8% (ESD), and 87.5% (ESD-S). No delayed bleeding occurred. One intraprocedural perforation occurred, it improved with conservative management. Four delayed perforations occurred; three required surgery and one was treated conservatively. Ninety-six patients had ≥ 12 months of follow-up; two (2.1%) developed local recurrence and underwent repeat endoscopic treatment, with no further recurrence.
CONCLUSION
ER for SNADTs is safe and effective. In addition to EMR and ESD, a modified ESD technique (ESD-S) is effective. Endoscopic therapy is a viable and effective option for recurrence.
Core Tip: Sporadic nonampullary duodenal tumors (SNADTs) are uncommon neoplasms in clinical practice. Endoscopic resection (ER) has become a widely adopted therapeutic modality for these lesions. Our study evaluates the outcomes of ER for nonampullay duodenal tumors to assess its efficacy and safety. ER for SNADTs is a safe and effective treatment strategy. Endoscopic therapy represents a viable first-line option for appropriately selected patients, offering favorable oncologic outcomes. Long-term follow-up and careful endoscopic surveillance are recommended to ensure early detection and management of potential recurrences.
