Ye LP, Zhang YP, Chen G, Wu YX, He CL, Wang D, Mei Q. Combined multidetector computed tomography and gastrointestinal endoscopy for gastric cancer screening, preoperative staging, and lymph node metastasis detection. World J Gastrointest Oncol 2026; 18(1): 113662 [PMID: 41607757 DOI: 10.4251/wjgo.v18.i1.113662]
Corresponding Author of This Article
Qiao Mei, MD, Chief Physician, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. meiqiao@hotmail.com
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Gastroenterology & Hepatology
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Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 15, 2026 (publication date) through Feb 1, 2026
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World Journal of Gastrointestinal Oncology
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1948-5204
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Ye LP, Zhang YP, Chen G, Wu YX, He CL, Wang D, Mei Q. Combined multidetector computed tomography and gastrointestinal endoscopy for gastric cancer screening, preoperative staging, and lymph node metastasis detection. World J Gastrointest Oncol 2026; 18(1): 113662 [PMID: 41607757 DOI: 10.4251/wjgo.v18.i1.113662]
World J Gastrointest Oncol. Jan 15, 2026; 18(1): 113662 Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.113662
Combined multidetector computed tomography and gastrointestinal endoscopy for gastric cancer screening, preoperative staging, and lymph node metastasis detection
Le-Ping Ye, Yan-Ping Zhang, Gang Chen, Yi-Xian Wu, Cheng-Long He, Dong Wang, Qiao Mei
Le-Ping Ye, Qiao Mei, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Le-Ping Ye, Yan-Ping Zhang, Gang Chen, Yi-Xian Wu, Department of Gastroenterology, Anqing Municipal Hospital, Anqing 246003, Anhui Province, China
Cheng-Long He, Department of General Surgery, Anqing Municipal Hospital, Anqing 246003, Anhui Province, China
Dong Wang, Department of Medical Imaging, Anqing Municipal Hospital, Anqing 246003, Anhui Province, China
Author contributions: Ye LP was responsible for the study design, data collection, and manuscript drafting; Zhang YP performed the data analysis and interpretation; Chen G, Wu YX, He CL, and Wang D participated in patient recruitment, clinical evaluation, and data curation; Mei Q supervised the entire research project and provided critical revisions to the manuscript. All authors read and approved the final version for submission.
Institutional review board statement: The procedures for both T1 and T2 surveys adhered to the Declaration of Helsinki, and ethical principles for medical, psychological, and sociological research involving human participants. The Anqing Municipal Hospital Research Ethics Committee approved the study protocol.
Informed consent statement: All individuals who participated in this study provided their written informed consent prior to study enrolment.
Conflict-of-interest statement: The authors declares that they have no conflicts of interest to report regarding the present study.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiao Mei, MD, Chief Physician, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. meiqiao@hotmail.com
Received: September 1, 2025 Revised: September 29, 2025 Accepted: November 14, 2025 Published online: January 15, 2026 Processing time: 134 Days and 18.2 Hours
Abstract
BACKGROUND
Early screening, preoperative staging, and diagnosis of lymph node metastasis are crucial for improving the prognosis of gastric cancer (GC).
AIM
To evaluate the diagnostic value of combined multidetector computed tomography (MDCT) and gastrointestinal endoscopy for GC screening, preoperative staging, and lymph node metastasis detection, thereby providing a reference for clinical diagnosis and treatment.
METHODS
In this retrospective study clinical and imaging data of 134 patients with suspected GC who were admitted between January 2023 and October 2024 were initially reviewed. According to the inclusion and exclusion criteria, 102 patients were finally enrolled in the analysis. All enrolled patients had undergone both MDCT and gastrointestinal endoscopy examinations prior to surgical intervention. Preoperative clinical staging and lymph node metastasis findings were compared with pathological results.
RESULTS
The combined use of MDCT and gastrointestinal endoscopy demonstrated a sensitivity of 98.53%, specificity of 97.06%, accuracy of 98.04%, positive predictive value of 98.53%, and negative predictive value of 97.06% for diagnosing GC. These factors were all significantly higher than those of MDCT or endoscopy alone (P < 0.05). The accuracy rates of the combined approach for detecting clinical T and N stages were 97.06% and 92.65%, respectively, outperforming MDCT alone (86.76% and 79.41%) and endoscopy alone (85.29% and 70.59%) (P < 0.05). Among 68 patients with confirmed GC, 50 (73.53%) were pathologically diagnosed with lymph node metastasis. The accuracy for detecting lymph node metastasis was 66.00% with endoscopy, 76.00% with MDCT, and 92.00% with the combined approach, all with statistically significant differences (P < 0.05).
CONCLUSION
The combined application of MDCT and gastrointestinal endoscopy enhanced diagnostic accuracy for GC, provided greater consistency in preoperative staging, and improved the detection of lymph node metastasis, thereby demonstrating significant clinical utility.
Core Tip: Combining multidetector computed tomography and gastrointestinal endoscopy significantly improved diagnostic performance for gastric cancer screening, preoperative T and N staging, and lymph node metastasis detection compared with either modality alone. The combined approach demonstrated superior sensitivity, specificity, and accuracy, offering greater concordance with postoperative pathological findings. This integrative strategy supports more informed clinical decision-making and optimized preoperative planning.
