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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Nov 16, 2025; 17(11): 112487
Published online Nov 16, 2025. doi: 10.4253/wjge.v17.i11.112487
Published online Nov 16, 2025. doi: 10.4253/wjge.v17.i11.112487
Endoscopic ultrasound features of pancreatic solid lesions: Descriptive and predictive analysis on a multicenter sample
Nunzio Zignani, Elia Fracas, Maurizio Vecchi, Gian Eugenio Tontini, Department of Pathophysiology and Transplantation, University of Milan, Milan 20122, Lombardy, Italy
Marco Balzarini, Laura Millefanti, Sergio Segato, Gastroenterology and Digestive Endoscopy Unit, ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese 21100, Lombardy, Italy
Emanuele Dabizzi, Maurizio Vecchi, Gian Eugenio Tontini, Flaminia Cavallaro, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan 20122, Lombardy, Italy
Gianpaolo Cengia, Guido Missale, Dario Moneghini, Digestive Endoscopy Unit, ASST Spedali Civili, Brescia 25123, Lombardy, Italy
Author contributions: Zignani N, Cavallaro F, Moneghini D and Balzarini M conceptualized the study; Zignani N, Cavallaro F, Tontini GE contributed to the methodology, formal analysis and original draft preparation; all the authors contributed to data curation and review and editing.
Supported by the Italian Ministry of Health - Current research IRCCS (Funds Dedicated to the Research of the Gastroenterology and Digestive Endoscopy Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano).
Institutional review board statement: This study was approved by the Ethical Committee Lombardia 3, dated April 17, 2024 (ID 4760 - opinion number 4760_17.04.2024_P).
Informed consent statement: Informed consent was not obtained in accordance with local ethical and privacy authorities, as it was deemed a disproportionate effort for the study and due to the demise of many patients enrolled before the study began.
Conflict-of-interest statement: The authors declare that they have no financial or non-financial conflicts of interest in relation to the publication of this article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The data are only accessible to the researchers and are handled in full compliance with local ethical and legal guidelines.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nunzio Zignani, MD, Department of Pathophysiology and Transp
Received: July 29, 2025
Revised: August 20, 2025
Accepted: October 17, 2025
Published online: November 16, 2025
Processing time: 108 Days and 22.4 Hours
Revised: August 20, 2025
Accepted: October 17, 2025
Published online: November 16, 2025
Processing time: 108 Days and 22.4 Hours
Core Tip
Core Tip: This multicenter observational study provides a broad overview of the endo-sonographic characteristics of solid pancreatic lesions, with detailed descriptions for each pathology and a predictive analysis of the most significant variables for key differential diagnoses. While existing literature touches on this topic, no prior study has analyzed endo-sonographic features with such a large sample size and comprehensive analysis. Our findings can aid clinical practice by optimizing the diagnostic process for solid pancreatic lesions, preventing both false negatives (delayed diagnosis) and false positives (unnecessary surgical intervention), and simultaneously supporting biopsy diagnosis when it is doubtful or inconclusive.