Dai HY, Liang X, Zhu YQ, Li Z. Pretraction-assisted endoscopic submucosal dissection for rectal neuroendocrine tumors: Efficacy and future directions. World J Gastrointest Endosc 2026; 18(2): 115174 [DOI: 10.4253/wjge.v18.i2.115174]
Corresponding Author of This Article
Zhen Li, MD, Chief Physician, Professor, Department of Gastroenterology, Qilu Hospital of Shandong University, No. 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. qilulizhen@sdu.edu.cn
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Gastroenterology & Hepatology
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Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 16, 2026 (publication date) through Feb 4, 2026
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World Journal of Gastrointestinal Endoscopy
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1948-5190
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Dai HY, Liang X, Zhu YQ, Li Z. Pretraction-assisted endoscopic submucosal dissection for rectal neuroendocrine tumors: Efficacy and future directions. World J Gastrointest Endosc 2026; 18(2): 115174 [DOI: 10.4253/wjge.v18.i2.115174]
World J Gastrointest Endosc. Feb 16, 2026; 18(2): 115174 Published online Feb 16, 2026. doi: 10.4253/wjge.v18.i2.115174
Pretraction-assisted endoscopic submucosal dissection for rectal neuroendocrine tumors: Efficacy and future directions
Hua-Yu Dai, Xiao Liang, Yi-Qing Zhu, Zhen Li
Hua-Yu Dai, Xiao Liang, Yi-Qing Zhu, Zhen Li, Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Dai HY wrote the original draft; Liang X, Zhu YQ, and Li Z contributed to writing, reviewing, and editing; Dai HY, Liang X, Zhu YQ, and Li Z participated in drafting the manuscript; Li Z contributed to conceptualization; and all authors have read and approved the final version of the manuscript.
Supported by the Taishan Scholars Program of Shandong Province, No. tsqn202306344.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen Li, MD, Chief Physician, Professor, Department of Gastroenterology, Qilu Hospital of Shandong University, No. 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. qilulizhen@sdu.edu.cn
Received: October 14, 2025 Revised: November 18, 2025 Accepted: December 19, 2025 Published online: February 16, 2026 Processing time: 115 Days and 22.1 Hours
Abstract
This article comments on a recent study by Guo et al demonstrating that pretraction-assisted endoscopic submucosal dissection (p-ESD) significantly improves treatment outcomes for rectal neuroendocrine tumors. Compared to conventional endoscopic submucosal dissection, p-ESD offers advantages such as shorter dissection time, higher R0 resection rates, and reduced incidence of complications. While acknowledging these encouraging findings, this study highlights key directions for future development: Elucidating the specific mechanisms of pretraction, establishing the generalizability of p-ESD through prospective multicenter studies, and validating its oncological efficacy through long-term follow-up. Addressing these issues is crucial for the broader application and standardization of p-ESD in clinical practice.
Core Tip: Pretraction-assisted endoscopic submucosal dissection is a safe and effective therapeutic technique for rectal neuroendocrine tumors. This significantly improves R0 resection rates and reduces the risk of adverse events. Further validation of the efficacy and generalizability of pretraction-assisted endoscopic submucosal dissection requires elucidating its specific mechanisms, conducting prospective multicenter studies, and performing long-term follow-up.
