Mitochondrial transplantation and platelet rich plasma for the treatment of non-alcoholic fatty liver disease

Figure 1 Multiple hit progression of non-alcoholic fatty liver disease. LPS: Lipopolysaccharides; ROS: Reactive oxygen species; ETC: Electron transport chain; DAG: Diacyl glycerol; CR: Ceramides; MDA: Malondialdehyde; 4-HNE: 4-hydroxynonenal; DNL: De novo lipogenesis; AC5L5: Long-chain fatty acyl-CoA ligase; Fabp1: Liver-specific fatty acid-binding protein 1; IL: Interleukin; TNF-α: Tumor necrosis factor α; NF-kβ: Nuclear factor-kappa B; VLDL: Very low density lipoprotein. Image provided by Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https://creativecommons.org/Licenses/by/4.0/).

Figure 2 Role of mitochondrial dysfunction in the progression of different stages of non-alcoholic fatty liver disease. Δψ: Mitochondrial membrane potential; ROS: Reactive oxygen species; FFA: Free fatty acids; ETC: Electron transport chain; Cyt c: Cytochrome c; TG: Triglycerides; ECM: Extracellular matrix; IL: Interleukin; TNF-α: Tumor necrosis factor α; NF-κB: Nuclear factor-kappa B. Image provided by Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https://creativecommons.org/Licenses/by/4.0/).