Mitochondrial transplantation and platelet rich plasma for the treatment of non-alcoholic fatty liver disease

doi:10.4254/wjh.v17.i10.110054

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Oct 27, 2025 (publication date) through Oct 27, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Oct 27, 2025; 17(10): 110054
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.110054

Mitochondrial transplantation and platelet rich plasma for the treatment of non-alcoholic fatty liver disease

Manuel Alejandro Vargas-Vargas, Marcela González-Montoya, Olin Torres-Isidro, Omar Ortiz-Avila, Elizabeth Calderón-Cortés, Christian Cortés-Rojo

Manuel Alejandro Vargas-Vargas, Marcela González-Montoya, Olin Torres-Isidro, Christian Cortés-Rojo, Instituto de Investigaciones Químico - Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Michoacán, Mexico

Omar Ortiz-Avila, Elizabeth Calderón-Cortés, Facultad de Enfermería, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58020, Michoacán, Mexico

Author contributions: Vargas-Vargas MA, González-Montoya M, Ortiz-Avila O, Calderón-Cortés E and Cortés-Rojo C performed the majority of research and writing; Torres-Isidro O prepared the figures and tables; Cortés-Rojo C designed the outline and coordinated the writing of the paper; all authors have read and approved the final manuscript.

Supported by Programa Proyectos de Investigación financiados 2025, Coordinación de Investigación Científica, Universidad Michoacana de San Nicolás de Hidalgo, México; and Secretaría de Ciencia, Humanidades, Tecnología e Innovación (SECIHTI), México Awarded Postdoctoral Fellowships, No. 472544 and No. 589763.

Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other co-authors contributed their efforts in this manuscript.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Christian Cortés-Rojo, PhD, Professor, Instituto de Investigaciones Químico - Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Ciudad Universitaria, Avenida Fco J Mujica, Morelia 58030, Michoacán, Mexico. christian.cortes@umich.mx

Received: May 28, 2025
Revised: June 26, 2025
Accepted: September 22, 2025
Published online: October 27, 2025
Processing time: 152 Days and 5.8 Hours

Core Tip

Core Tip: Liver diseases driven by mitochondrial dysfunction and oxidative stress have not yet been effectively treated, creating a need for novel therapeutic solutions. Mitochondrial transplantation restores energy metabolism, while platelet rich plasma (PRP) therapy reduces fibrosis via growth factors. This is the first review to propose the combination of mitochondrial transplantation and PRP as a novel therapeutic strategy for non-alcoholic fatty liver disease. The strategy addresses mitochondrial dysfunction, oxidative stress, and fibrosis while promoting liver regeneration, offering a promising alternative where pharmacological treatments are limited.