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World J Hepatol. Mar 27, 2026; 18(3): 113366
Published online Mar 27, 2026. doi: 10.4254/wjh.v18.i3.113366
Published online Mar 27, 2026. doi: 10.4254/wjh.v18.i3.113366
Fatigue assessment in Egyptian patients with hepatitis C virus-related chronic liver disease: Single center study
Marwa A Tahoon, Sally W Elkhadry, Department of Epidemiology and Preventive Medicine, National Liver Institute, Menoufia University, Shebin El Kom 32511, Egypt
Eman Abdelsameea, Reham Ashour, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El Kom 32511, Egypt
Author contributions: Elkhadry SW and Tahoon MA contributed to the conception and planning of the research; Elkhadry SW, Ashour R and Tahoon MA conducted the administration; Ashour R conducted the data collation; Tahoon MA conducted the statistical data analysis; Tahoon MA and Elkhadry SW were involving the data interpretation; Elkhadry SW, Ashour R, Tahoon MA, and Abdelsameea E authored the initial draft; Elkhadry SW, Tahoon MA, Abdelsameea E, Elkhadry SW, and Ashour R conducted the subsequent review and editing; all authors supervised the editing and preparation of the final text for publication.
Institutional review board statement: The research received approval from the Institutional Review Board of the National Liver Institute (NLI IRB 00014014), NLI IRB protocol No. 00632/2024.
Informed consent statement: Upon being fully apprised of the investigation's objectives, all participants in the investigation provided signed informed consent prior to recruitment. All participants have been informed that their responses & data would be treated with the utmost confidentially and that they might withdraw from the investigation at any time without consequences.
Conflict-of-interest statement: The authors declared that they have no competing interests.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.
Data sharing statement: Any interested person may have access to the datasets utilized in this study by reaching out to the corresponding author.
Corresponding author: Eman Abdelsameea, Professor, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Gamal Abdelnasser Street, Shebin El Kom 32511, Egypt. eabdelsameea@liver-eg.org
Received: August 25, 2025
Revised: September 30, 2025
Accepted: January 8, 2026
Published online: March 27, 2026
Processing time: 215 Days and 15.2 Hours
Revised: September 30, 2025
Accepted: January 8, 2026
Published online: March 27, 2026
Processing time: 215 Days and 15.2 Hours
Core Tip
Core Tip: Chronic hepatitis C virus (HCV) infection is often associated with fatigue. We recruited 300 chronic HCV patients. Fatigue has been evaluated with multidimensional fatigue inventory-20 (validated tool to assess different dimensions of fatigue in this population. Significant/severe fatigue was prevalent in 27.3% of HCV patients. Decompensated liver disease, intermediate/high-risk fibrosis, < 1 year duration of last dose of antiviral treatment, and HCV infection duration were independent risk factors for fatigue. Fatigue is a widespread and complex symptom in cases with chronic HCV, closely linked to liver disease severity, antiviral treatment, and infection duration.