Qin JW, Wu JC, Zheng H, Qi C, Zhu ZB, Li XF, Wang N, Yuan XD, Xu ZJ, Wu W, Zhang SG, Nashan B. De novo schizophrenia after liver transplantation: A case report. World J Hepatol 2026; 18(1): 114291 [DOI: 10.4254/wjh.v18.i1.114291]
Corresponding Author of This Article
Björn Nashan, MD, PhD, FACS, FRCS (Gen Surg), Professor, Department of Liver Transplantation, The First Affiliated Hospital of USTC, Hezeji Street, Shushan District, Hefei 230000, Anhui Province, China. bjoern.nashan@gmail.com
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Transplantation
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Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 27, 2026 (publication date) through Jan 27, 2026
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Publication Name
World Journal of Hepatology
ISSN
1948-5182
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Qin JW, Wu JC, Zheng H, Qi C, Zhu ZB, Li XF, Wang N, Yuan XD, Xu ZJ, Wu W, Zhang SG, Nashan B. De novo schizophrenia after liver transplantation: A case report. World J Hepatol 2026; 18(1): 114291 [DOI: 10.4254/wjh.v18.i1.114291]
World J Hepatol. Jan 27, 2026; 18(1): 114291 Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.114291
De novo schizophrenia after liver transplantation: A case report
Ji-Wei Qin, Jian-Cheng Wu, Hao Zheng, Can Qi, Ze-Bin Zhu, Xue-Feng Li, Ning Wang, Xiao-Dong Yuan, Zhi-Jun Xu, Wei Wu, Shu-Geng Zhang, Björn Nashan
Ji-Wei Qin, Jian-Cheng Wu, Hao Zheng, Can Qi, Ze-Bin Zhu, Xue-Feng Li, Ning Wang, Xiao-Dong Yuan, Zhi-Jun Xu, Wei Wu, Department of Organ Transplantation Center, The First Affiliated Hospital of USTC, Hefei 230000, Anhui Province, China
Jian-Cheng Wu, Graduate School of Bengbu Medical University, Bengbu Medical University, Bengbu 233000, Anhui Province, China
Shu-Geng Zhang, Björn Nashan, Department of Liver Transplantation, The First Affiliated Hospital of USTC, Hefei 230000, Anhui Province, China
Co-first authors: Ji-Wei Qin and Jian-Cheng Wu.
Co-corresponding authors: Shu-Geng Zhang and Björn Nashan.
Author contributions: Qin JW and Wu JC contributed to manuscript writing and editing, data collection, and they contributed equally to this manuscript and are co-first authors; Qin JW contributed to literature review; Zheng H, Qi C, Zhu ZB, Li XF, Wang N, Yuan XD, Xu ZJ, and Wu W contributed to the treatment and management of the patient; Zhang SG contributed to the liver transplantation operation; Nashan B contributed to conceptualization and supervision; Zhang SG and Nashan B contributed equally to this manuscript and are co-corresponding authors. All authors contributed to the drafting of the manuscript, and read and approved the final version.
Supported by Anhui Provincial Outstanding Youth Research Foundation for Higher Education Institutions of China, No. 2022AH020077.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Björn Nashan, MD, PhD, FACS, FRCS (Gen Surg), Professor, Department of Liver Transplantation, The First Affiliated Hospital of USTC, Hezeji Street, Shushan District, Hefei 230000, Anhui Province, China. bjoern.nashan@gmail.com
Received: September 18, 2025 Revised: November 2, 2025 Accepted: December 9, 2025 Published online: January 27, 2026 Processing time: 131 Days and 15.7 Hours
Core Tip
Core Tip: We present the inaugural instance of new-onset schizophrenia occurring within one year post-liver transplantation in a 63-year-old female patient. The diagnosis was determined using structured interviews, sequential Positive and Negative Syndrome Scale scores, and thorough exclusion of metabolic, viral, and toxic variables. Following the commencement of antipsychotic treatment alongside low-dose tacrolimus and mycofenolate mofetil immunosuppression, the patient showed rapid improvement of symptoms, indicating calcineurin-inhibitor neurotoxicity as a direct catalyst; and surgical stress and anesthesia likely exacerbated individual vulnerability. This instance highlights the necessity for proactive neuropsychiatric monitoring and tailored immunosuppression in liver transplant recipients.
